Influenza virus activation of the interferon system

The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summ...

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Detalles Bibliográficos
Autores principales: Killip, Marian J., Fodor, Ervin, Randall, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638190/
https://www.ncbi.nlm.nih.gov/pubmed/25678267
http://dx.doi.org/10.1016/j.virusres.2015.02.003
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author Killip, Marian J.
Fodor, Ervin
Randall, Richard E.
author_facet Killip, Marian J.
Fodor, Ervin
Randall, Richard E.
author_sort Killip, Marian J.
collection PubMed
description The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process.
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spelling pubmed-46381902015-12-03 Influenza virus activation of the interferon system Killip, Marian J. Fodor, Ervin Randall, Richard E. Virus Res Article The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. Many advances have been made in recent years in understanding the interactions between influenza viruses and the interferon system. In this review, we summarise recent work regarding activation of the type I IFN response by influenza viruses, including attempts to identify the viral RNA responsible for IFN induction, the stage of the virus life cycle at which it is generated and the role of defective viruses in this process. Elsevier Science 2015-11-02 /pmc/articles/PMC4638190/ /pubmed/25678267 http://dx.doi.org/10.1016/j.virusres.2015.02.003 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Killip, Marian J.
Fodor, Ervin
Randall, Richard E.
Influenza virus activation of the interferon system
title Influenza virus activation of the interferon system
title_full Influenza virus activation of the interferon system
title_fullStr Influenza virus activation of the interferon system
title_full_unstemmed Influenza virus activation of the interferon system
title_short Influenza virus activation of the interferon system
title_sort influenza virus activation of the interferon system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638190/
https://www.ncbi.nlm.nih.gov/pubmed/25678267
http://dx.doi.org/10.1016/j.virusres.2015.02.003
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