Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway

OBJECTIVE: To define how the catabolic cytokines (Interleukin 1 (IL-1) and tumor necrosis factor alpha (TNFα)) affect the circadian clock mechanism and the expression of clock-controlled catabolic genes within cartilage, and to identify the downstream pathways linking the cytokines to the molecular...

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Detalles Bibliográficos
Autores principales: Guo, B., Yang, N., Borysiewicz, E., Dudek, M., Williams, J.L., Li, J., Maywood, E.S., Adamson, A., Hastings, M.H., Bateman, J.F., White, M.R.H., Boot-Handford, R.P., Meng, Q.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638193/
https://www.ncbi.nlm.nih.gov/pubmed/26521744
http://dx.doi.org/10.1016/j.joca.2015.02.020

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