Cargando…

Deficits of learning and memory in Hemojuvelin knockout mice

Iron is involved in various physiological processes of the human body to maintain normal functions. Abnormal iron accumulation in brain has been reported as a pathogenesis of several neurodegenerative disorders and cognitive impairments. Hemojuvelin (HVJ) is a membrane-bound and soluble protein in m...

Descripción completa

Detalles Bibliográficos
Autores principales: LI, Jinglong, ZHANG, Peng, LIU, Hongju, REN, Wei, SONG, Jinjing, RAO, Elizabeth, TAKAHASHI, Eiki, ZHOU, Ying, LI, Weidong, CHEN, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638289/
https://www.ncbi.nlm.nih.gov/pubmed/26027705
http://dx.doi.org/10.1292/jvms.15-0102
_version_ 1782399891313524736
author LI, Jinglong
ZHANG, Peng
LIU, Hongju
REN, Wei
SONG, Jinjing
RAO, Elizabeth
TAKAHASHI, Eiki
ZHOU, Ying
LI, Weidong
CHEN, Xiaoping
author_facet LI, Jinglong
ZHANG, Peng
LIU, Hongju
REN, Wei
SONG, Jinjing
RAO, Elizabeth
TAKAHASHI, Eiki
ZHOU, Ying
LI, Weidong
CHEN, Xiaoping
author_sort LI, Jinglong
collection PubMed
description Iron is involved in various physiological processes of the human body to maintain normal functions. Abnormal iron accumulation in brain has been reported as a pathogenesis of several neurodegenerative disorders and cognitive impairments. Hemojuvelin (HVJ) is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis. Although iron accumulation in brain has been related to neurodegenerative diseases, it remains unknown the effect of mutation of HVJ gene on cognitive performance. In our studies, HJV(−/−) mice showed deficits in novel object recognition and Morris water maze tests. Furthermore, the expression ration of apoptotic marker Bax and anti-apoptotic marker Bcl-2 in the hippocampus and prefrontal cortex showed higher levels in HJV(−/−) mice. Our results suggested that deletion of HJV gene could increase apoptosis in brain which might contribute to learning and memory deficits in mutant mice. These results indicated that HJV(−/−) mice would be a useful model to study cognitive impairment induced by iron overload in brain.
format Online
Article
Text
id pubmed-4638289
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The Japanese Society of Veterinary Science
record_format MEDLINE/PubMed
spelling pubmed-46382892015-11-10 Deficits of learning and memory in Hemojuvelin knockout mice LI, Jinglong ZHANG, Peng LIU, Hongju REN, Wei SONG, Jinjing RAO, Elizabeth TAKAHASHI, Eiki ZHOU, Ying LI, Weidong CHEN, Xiaoping J Vet Med Sci Laboratory Animal Science Iron is involved in various physiological processes of the human body to maintain normal functions. Abnormal iron accumulation in brain has been reported as a pathogenesis of several neurodegenerative disorders and cognitive impairments. Hemojuvelin (HVJ) is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis. Although iron accumulation in brain has been related to neurodegenerative diseases, it remains unknown the effect of mutation of HVJ gene on cognitive performance. In our studies, HJV(−/−) mice showed deficits in novel object recognition and Morris water maze tests. Furthermore, the expression ration of apoptotic marker Bax and anti-apoptotic marker Bcl-2 in the hippocampus and prefrontal cortex showed higher levels in HJV(−/−) mice. Our results suggested that deletion of HJV gene could increase apoptosis in brain which might contribute to learning and memory deficits in mutant mice. These results indicated that HJV(−/−) mice would be a useful model to study cognitive impairment induced by iron overload in brain. The Japanese Society of Veterinary Science 2015-05-29 2015-10 /pmc/articles/PMC4638289/ /pubmed/26027705 http://dx.doi.org/10.1292/jvms.15-0102 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Laboratory Animal Science
LI, Jinglong
ZHANG, Peng
LIU, Hongju
REN, Wei
SONG, Jinjing
RAO, Elizabeth
TAKAHASHI, Eiki
ZHOU, Ying
LI, Weidong
CHEN, Xiaoping
Deficits of learning and memory in Hemojuvelin knockout mice
title Deficits of learning and memory in Hemojuvelin knockout mice
title_full Deficits of learning and memory in Hemojuvelin knockout mice
title_fullStr Deficits of learning and memory in Hemojuvelin knockout mice
title_full_unstemmed Deficits of learning and memory in Hemojuvelin knockout mice
title_short Deficits of learning and memory in Hemojuvelin knockout mice
title_sort deficits of learning and memory in hemojuvelin knockout mice
topic Laboratory Animal Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638289/
https://www.ncbi.nlm.nih.gov/pubmed/26027705
http://dx.doi.org/10.1292/jvms.15-0102
work_keys_str_mv AT lijinglong deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT zhangpeng deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT liuhongju deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT renwei deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT songjinjing deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT raoelizabeth deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT takahashieiki deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT zhouying deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT liweidong deficitsoflearningandmemoryinhemojuvelinknockoutmice
AT chenxiaoping deficitsoflearningandmemoryinhemojuvelinknockoutmice