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Deficits of learning and memory in Hemojuvelin knockout mice
Iron is involved in various physiological processes of the human body to maintain normal functions. Abnormal iron accumulation in brain has been reported as a pathogenesis of several neurodegenerative disorders and cognitive impairments. Hemojuvelin (HVJ) is a membrane-bound and soluble protein in m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638289/ https://www.ncbi.nlm.nih.gov/pubmed/26027705 http://dx.doi.org/10.1292/jvms.15-0102 |
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author | LI, Jinglong ZHANG, Peng LIU, Hongju REN, Wei SONG, Jinjing RAO, Elizabeth TAKAHASHI, Eiki ZHOU, Ying LI, Weidong CHEN, Xiaoping |
author_facet | LI, Jinglong ZHANG, Peng LIU, Hongju REN, Wei SONG, Jinjing RAO, Elizabeth TAKAHASHI, Eiki ZHOU, Ying LI, Weidong CHEN, Xiaoping |
author_sort | LI, Jinglong |
collection | PubMed |
description | Iron is involved in various physiological processes of the human body to maintain normal functions. Abnormal iron accumulation in brain has been reported as a pathogenesis of several neurodegenerative disorders and cognitive impairments. Hemojuvelin (HVJ) is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis. Although iron accumulation in brain has been related to neurodegenerative diseases, it remains unknown the effect of mutation of HVJ gene on cognitive performance. In our studies, HJV(−/−) mice showed deficits in novel object recognition and Morris water maze tests. Furthermore, the expression ration of apoptotic marker Bax and anti-apoptotic marker Bcl-2 in the hippocampus and prefrontal cortex showed higher levels in HJV(−/−) mice. Our results suggested that deletion of HJV gene could increase apoptosis in brain which might contribute to learning and memory deficits in mutant mice. These results indicated that HJV(−/−) mice would be a useful model to study cognitive impairment induced by iron overload in brain. |
format | Online Article Text |
id | pubmed-4638289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46382892015-11-10 Deficits of learning and memory in Hemojuvelin knockout mice LI, Jinglong ZHANG, Peng LIU, Hongju REN, Wei SONG, Jinjing RAO, Elizabeth TAKAHASHI, Eiki ZHOU, Ying LI, Weidong CHEN, Xiaoping J Vet Med Sci Laboratory Animal Science Iron is involved in various physiological processes of the human body to maintain normal functions. Abnormal iron accumulation in brain has been reported as a pathogenesis of several neurodegenerative disorders and cognitive impairments. Hemojuvelin (HVJ) is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis. Although iron accumulation in brain has been related to neurodegenerative diseases, it remains unknown the effect of mutation of HVJ gene on cognitive performance. In our studies, HJV(−/−) mice showed deficits in novel object recognition and Morris water maze tests. Furthermore, the expression ration of apoptotic marker Bax and anti-apoptotic marker Bcl-2 in the hippocampus and prefrontal cortex showed higher levels in HJV(−/−) mice. Our results suggested that deletion of HJV gene could increase apoptosis in brain which might contribute to learning and memory deficits in mutant mice. These results indicated that HJV(−/−) mice would be a useful model to study cognitive impairment induced by iron overload in brain. The Japanese Society of Veterinary Science 2015-05-29 2015-10 /pmc/articles/PMC4638289/ /pubmed/26027705 http://dx.doi.org/10.1292/jvms.15-0102 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Laboratory Animal Science LI, Jinglong ZHANG, Peng LIU, Hongju REN, Wei SONG, Jinjing RAO, Elizabeth TAKAHASHI, Eiki ZHOU, Ying LI, Weidong CHEN, Xiaoping Deficits of learning and memory in Hemojuvelin knockout mice |
title | Deficits of learning and memory in Hemojuvelin knockout mice |
title_full | Deficits of learning and memory in Hemojuvelin knockout mice |
title_fullStr | Deficits of learning and memory in Hemojuvelin knockout mice |
title_full_unstemmed | Deficits of learning and memory in Hemojuvelin knockout mice |
title_short | Deficits of learning and memory in Hemojuvelin knockout mice |
title_sort | deficits of learning and memory in hemojuvelin knockout mice |
topic | Laboratory Animal Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638289/ https://www.ncbi.nlm.nih.gov/pubmed/26027705 http://dx.doi.org/10.1292/jvms.15-0102 |
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