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Prevalence of amyloid deposition in mature healthy chickens in the flock that previously had outbreaks of vaccine-associated amyloidosis
Avian amyloid A (AA) amyloidosis is commonly observed in adult birds with chronic inflammation, such as that caused by bacterial infection. We previously described vaccine-associated AA amyloidosis in juvenile chickens. In this study, the prevalence of amyloid deposition was measured in mature healt...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638290/ https://www.ncbi.nlm.nih.gov/pubmed/25985816 http://dx.doi.org/10.1292/jvms.15-0029 |
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author | IBI, Kanata MURAKAMI, Tomoaki GODA, Wael Mohamed KOBAYASHI, Naoki ISHIGURO, Naotaka YANAI, Tokuma |
author_facet | IBI, Kanata MURAKAMI, Tomoaki GODA, Wael Mohamed KOBAYASHI, Naoki ISHIGURO, Naotaka YANAI, Tokuma |
author_sort | IBI, Kanata |
collection | PubMed |
description | Avian amyloid A (AA) amyloidosis is commonly observed in adult birds with chronic inflammation, such as that caused by bacterial infection. We previously described vaccine-associated AA amyloidosis in juvenile chickens. In this study, the prevalence of amyloid deposition was measured in mature healthy chickens that survived a previous outbreak of avian AA amyloidosis while they were juveniles. Herein, we analyzed the amyloid deposition in mature chickens and compared the prevalence of amyloid deposition with juvenile chickens obtained in our previous study (Murakami et al., 2013). We found that: 1) amyloid deposition in the liver was absent in mature chickens, while juvenile chickens had a rate of 24%; 2) amyloid deposition in the spleen was observed in 36% of juvenile chickens and in 40% of mature chickens; 3) amyloid deposition in the pectoral muscle of mature chickens (43.75%) was approximately half that of juvenile chickens (88%). These results suggest that additional amyloid deposition in chickens previously exposed to AA amyloidosis may not worsen with age. Further, amyloid deposition in chickens may tend to regress when causative factors, such as vaccinations and/or chronic inflammation, are absent. |
format | Online Article Text |
id | pubmed-4638290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46382902015-11-10 Prevalence of amyloid deposition in mature healthy chickens in the flock that previously had outbreaks of vaccine-associated amyloidosis IBI, Kanata MURAKAMI, Tomoaki GODA, Wael Mohamed KOBAYASHI, Naoki ISHIGURO, Naotaka YANAI, Tokuma J Vet Med Sci Pathology Avian amyloid A (AA) amyloidosis is commonly observed in adult birds with chronic inflammation, such as that caused by bacterial infection. We previously described vaccine-associated AA amyloidosis in juvenile chickens. In this study, the prevalence of amyloid deposition was measured in mature healthy chickens that survived a previous outbreak of avian AA amyloidosis while they were juveniles. Herein, we analyzed the amyloid deposition in mature chickens and compared the prevalence of amyloid deposition with juvenile chickens obtained in our previous study (Murakami et al., 2013). We found that: 1) amyloid deposition in the liver was absent in mature chickens, while juvenile chickens had a rate of 24%; 2) amyloid deposition in the spleen was observed in 36% of juvenile chickens and in 40% of mature chickens; 3) amyloid deposition in the pectoral muscle of mature chickens (43.75%) was approximately half that of juvenile chickens (88%). These results suggest that additional amyloid deposition in chickens previously exposed to AA amyloidosis may not worsen with age. Further, amyloid deposition in chickens may tend to regress when causative factors, such as vaccinations and/or chronic inflammation, are absent. The Japanese Society of Veterinary Science 2015-05-18 2015-10 /pmc/articles/PMC4638290/ /pubmed/25985816 http://dx.doi.org/10.1292/jvms.15-0029 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Pathology IBI, Kanata MURAKAMI, Tomoaki GODA, Wael Mohamed KOBAYASHI, Naoki ISHIGURO, Naotaka YANAI, Tokuma Prevalence of amyloid deposition in mature healthy chickens in the flock that previously had outbreaks of vaccine-associated amyloidosis |
title | Prevalence of amyloid deposition in mature healthy chickens in the flock that
previously had outbreaks of vaccine-associated amyloidosis |
title_full | Prevalence of amyloid deposition in mature healthy chickens in the flock that
previously had outbreaks of vaccine-associated amyloidosis |
title_fullStr | Prevalence of amyloid deposition in mature healthy chickens in the flock that
previously had outbreaks of vaccine-associated amyloidosis |
title_full_unstemmed | Prevalence of amyloid deposition in mature healthy chickens in the flock that
previously had outbreaks of vaccine-associated amyloidosis |
title_short | Prevalence of amyloid deposition in mature healthy chickens in the flock that
previously had outbreaks of vaccine-associated amyloidosis |
title_sort | prevalence of amyloid deposition in mature healthy chickens in the flock that
previously had outbreaks of vaccine-associated amyloidosis |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638290/ https://www.ncbi.nlm.nih.gov/pubmed/25985816 http://dx.doi.org/10.1292/jvms.15-0029 |
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