Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells

VP22 is a major tegument protein of Equine herpesvirus type 1 (EHV-1) that is a conserved protein among alphaherpesviruses. However, the roles of VP22 differ among each virus, and the roles of EHV-1 VP22 are still unclear. Here, we constructed an EHV-1 VP22 deletion mutant and a revertant virus to c...

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Autores principales: OKADA, Ayaka, IZUME, Satoko, OHYA, Kenji, FUKUSHI, Hideto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2015
Materias:
Virology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638299/
https://www.ncbi.nlm.nih.gov/pubmed/25948053
http://dx.doi.org/10.1292/jvms.14-0648
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author OKADA, Ayaka
IZUME, Satoko
OHYA, Kenji
FUKUSHI, Hideto
author_facet OKADA, Ayaka
IZUME, Satoko
OHYA, Kenji
FUKUSHI, Hideto
author_sort OKADA, Ayaka
collection PubMed
description VP22 is a major tegument protein of Equine herpesvirus type 1 (EHV-1) that is a conserved protein among alphaherpesviruses. However, the roles of VP22 differ among each virus, and the roles of EHV-1 VP22 are still unclear. Here, we constructed an EHV-1 VP22 deletion mutant and a revertant virus to clarify the role of VP22. We found that EHV-1 VP22 was required for efficient viral growth in cultured cells, but not for virulence in a hamster model.
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spelling pubmed-46382992015-11-10 Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells OKADA, Ayaka IZUME, Satoko OHYA, Kenji FUKUSHI, Hideto J Vet Med Sci Virology VP22 is a major tegument protein of Equine herpesvirus type 1 (EHV-1) that is a conserved protein among alphaherpesviruses. However, the roles of VP22 differ among each virus, and the roles of EHV-1 VP22 are still unclear. Here, we constructed an EHV-1 VP22 deletion mutant and a revertant virus to clarify the role of VP22. We found that EHV-1 VP22 was required for efficient viral growth in cultured cells, but not for virulence in a hamster model. The Japanese Society of Veterinary Science 2015-05-07 2015-10 /pmc/articles/PMC4638299/ /pubmed/25948053 http://dx.doi.org/10.1292/jvms.14-0648 Text en ©2015 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Virology
OKADA, Ayaka
IZUME, Satoko
OHYA, Kenji
FUKUSHI, Hideto
Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells
title Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells
title_full Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells
title_fullStr Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells
title_full_unstemmed Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells
title_short Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells
title_sort equine herpesvirus type 1 tegument protein vp22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638299/
https://www.ncbi.nlm.nih.gov/pubmed/25948053
http://dx.doi.org/10.1292/jvms.14-0648
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