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Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T
For different functional magnetic resonance imaging experiments using blood oxygenation level-dependent (BOLD) contrast, the acquisition of T (2)*-weighted scans at a high spatial resolution may be advantageous in terms of time-course signal-to-noise ratio and of BOLD sensitivity when the regions ar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638337/ https://www.ncbi.nlm.nih.gov/pubmed/26550990 http://dx.doi.org/10.1371/journal.pone.0141358 |
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author | Iranpour, Juliana Morrot, Gil Claise, Béatrice Jean, Betty Bonny, Jean-Marie |
author_facet | Iranpour, Juliana Morrot, Gil Claise, Béatrice Jean, Betty Bonny, Jean-Marie |
author_sort | Iranpour, Juliana |
collection | PubMed |
description | For different functional magnetic resonance imaging experiments using blood oxygenation level-dependent (BOLD) contrast, the acquisition of T (2)*-weighted scans at a high spatial resolution may be advantageous in terms of time-course signal-to-noise ratio and of BOLD sensitivity when the regions are prone to susceptibility artifacts. In this study, we explore this solution by examining how spatial resolution influences activations elicited when appetizing food pictures are viewed. Twenty subjects were imaged at 3 T with two different voxel volumes, 3.4 μl and 27 μl. Despite the diminution of brain coverage, we found that high-resolution acquisition led to a better detection of activations. Though known to suffer to different degrees from susceptibility artifacts, the activations detected by high spatial resolution were notably consistent with those reported in published activation likelihood estimation meta-analyses, corresponding to taste-responsive regions. Furthermore, these regions were found activated bilaterally, in contrast with previous findings. Both the reduction of partial volume effect, which improves BOLD contrast, and the mitigation of susceptibility artifact, which boosts the signal to noise ratio in certain regions, explained the better detection noted with high resolution. The present study provides further evidences that high spatial resolution is a valuable solution for human BOLD fMRI, especially for studying food-related stimuli. |
format | Online Article Text |
id | pubmed-4638337 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46383372015-11-13 Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T Iranpour, Juliana Morrot, Gil Claise, Béatrice Jean, Betty Bonny, Jean-Marie PLoS One Research Article For different functional magnetic resonance imaging experiments using blood oxygenation level-dependent (BOLD) contrast, the acquisition of T (2)*-weighted scans at a high spatial resolution may be advantageous in terms of time-course signal-to-noise ratio and of BOLD sensitivity when the regions are prone to susceptibility artifacts. In this study, we explore this solution by examining how spatial resolution influences activations elicited when appetizing food pictures are viewed. Twenty subjects were imaged at 3 T with two different voxel volumes, 3.4 μl and 27 μl. Despite the diminution of brain coverage, we found that high-resolution acquisition led to a better detection of activations. Though known to suffer to different degrees from susceptibility artifacts, the activations detected by high spatial resolution were notably consistent with those reported in published activation likelihood estimation meta-analyses, corresponding to taste-responsive regions. Furthermore, these regions were found activated bilaterally, in contrast with previous findings. Both the reduction of partial volume effect, which improves BOLD contrast, and the mitigation of susceptibility artifact, which boosts the signal to noise ratio in certain regions, explained the better detection noted with high resolution. The present study provides further evidences that high spatial resolution is a valuable solution for human BOLD fMRI, especially for studying food-related stimuli. Public Library of Science 2015-11-09 /pmc/articles/PMC4638337/ /pubmed/26550990 http://dx.doi.org/10.1371/journal.pone.0141358 Text en © 2015 Iranpour et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Iranpour, Juliana Morrot, Gil Claise, Béatrice Jean, Betty Bonny, Jean-Marie Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T |
title | Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T |
title_full | Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T |
title_fullStr | Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T |
title_full_unstemmed | Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T |
title_short | Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T |
title_sort | using high spatial resolution to improve bold fmri detection at 3t |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638337/ https://www.ncbi.nlm.nih.gov/pubmed/26550990 http://dx.doi.org/10.1371/journal.pone.0141358 |
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