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Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer

OBJECTIVES: Previous non–simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using...

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Autores principales: Brandmaier, P., Purz, S., Bremicker, K., Höckel, M., Barthel, H., Kluge, R., Kahn, T., Sabri, O., Stumpp, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638340/
https://www.ncbi.nlm.nih.gov/pubmed/26551527
http://dx.doi.org/10.1371/journal.pone.0141684
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author Brandmaier, P.
Purz, S.
Bremicker, K.
Höckel, M.
Barthel, H.
Kluge, R.
Kahn, T.
Sabri, O.
Stumpp, P.
author_facet Brandmaier, P.
Purz, S.
Bremicker, K.
Höckel, M.
Barthel, H.
Kluge, R.
Kahn, T.
Sabri, O.
Stumpp, P.
author_sort Brandmaier, P.
collection PubMed
description OBJECTIVES: Previous non–simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using a simultaneous PET/MRI system which could lead to a better understanding of tumor biology and might play a role in early response assessment. METHODS: We included 31 patients with histologically confirmed primary (n = 14) or recurrent cervical cancer (n = 17) who underwent simultaneous whole-body (18)F-FDG-PET/MRI comprising DWI. Image analysis was performed by a radiologist and a nuclear physician who identified tumor margins and quantified ADC and SUV. Pearson correlations were calculated to investigate the association between ADC and SUV. RESULTS: 92 lesions were detected. We found a significant inverse correlation between SUV(max) and ADC(min) (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUV(mean) and ADC(min) (r = -0.403, p = 0.03). In recurrent local tumors we found correlations for SUV(max) and ADC(min) (r = -0.747, p = 0.002) and SUV(mean) and ADC(min) (r = -0.773, p = 0.001). Associations for recurrent metastases were not significant (p>0.05). CONCLUSIONS: Our study demonstrates the feasibility of fast and reliable measurement of SUV and ADC with simultaneous PET/MRI. In patients with cervical cancer we found significant inverse correlations for SUV and ADC which could play a major role for further tumor characterization and therapy decisions.
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spelling pubmed-46383402015-11-13 Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer Brandmaier, P. Purz, S. Bremicker, K. Höckel, M. Barthel, H. Kluge, R. Kahn, T. Sabri, O. Stumpp, P. PLoS One Research Article OBJECTIVES: Previous non–simultaneous PET/MR studies have shown heterogeneous results about the correlation between standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs). The aim of this study was to investigate correlations in patients with primary and recurrent tumors using a simultaneous PET/MRI system which could lead to a better understanding of tumor biology and might play a role in early response assessment. METHODS: We included 31 patients with histologically confirmed primary (n = 14) or recurrent cervical cancer (n = 17) who underwent simultaneous whole-body (18)F-FDG-PET/MRI comprising DWI. Image analysis was performed by a radiologist and a nuclear physician who identified tumor margins and quantified ADC and SUV. Pearson correlations were calculated to investigate the association between ADC and SUV. RESULTS: 92 lesions were detected. We found a significant inverse correlation between SUV(max) and ADC(min) (r = -0.532, p = 0.05) in primary tumors as well as in primary metastases (r = -0.362, p = 0.05) and between SUV(mean) and ADC(min) (r = -0.403, p = 0.03). In recurrent local tumors we found correlations for SUV(max) and ADC(min) (r = -0.747, p = 0.002) and SUV(mean) and ADC(min) (r = -0.773, p = 0.001). Associations for recurrent metastases were not significant (p>0.05). CONCLUSIONS: Our study demonstrates the feasibility of fast and reliable measurement of SUV and ADC with simultaneous PET/MRI. In patients with cervical cancer we found significant inverse correlations for SUV and ADC which could play a major role for further tumor characterization and therapy decisions. Public Library of Science 2015-11-09 /pmc/articles/PMC4638340/ /pubmed/26551527 http://dx.doi.org/10.1371/journal.pone.0141684 Text en © 2015 Brandmaier et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Brandmaier, P.
Purz, S.
Bremicker, K.
Höckel, M.
Barthel, H.
Kluge, R.
Kahn, T.
Sabri, O.
Stumpp, P.
Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer
title Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer
title_full Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer
title_fullStr Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer
title_full_unstemmed Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer
title_short Simultaneous [(18)F]FDG-PET/MRI: Correlation of Apparent Diffusion Coefficient (ADC) and Standardized Uptake Value (SUV) in Primary and Recurrent Cervical Cancer
title_sort simultaneous [(18)f]fdg-pet/mri: correlation of apparent diffusion coefficient (adc) and standardized uptake value (suv) in primary and recurrent cervical cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638340/
https://www.ncbi.nlm.nih.gov/pubmed/26551527
http://dx.doi.org/10.1371/journal.pone.0141684
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