Sculpting the proteome with small molecules

The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the princi...

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Detalles Bibliográficos
Autores principales: King, Randall W, Finley, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639395/
https://www.ncbi.nlm.nih.gov/pubmed/25325686
http://dx.doi.org/10.1038/nchembio.1671
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author King, Randall W
Finley, Daniel
author_facet King, Randall W
Finley, Daniel
author_sort King, Randall W
collection PubMed
description The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the principles that underlie the development of effective inhibitors or activators of the pathway. We emphasize insights from structural analysis and describe strategies for evaluating the selectivity of compounds.
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spelling pubmed-46393952015-11-09 Sculpting the proteome with small molecules King, Randall W Finley, Daniel Nat Chem Biol Article The ubiquitin-proteasome system (UPS) pervades the biology of eukaryotes. Because it depends on the activity of hundreds of different enzymes and protein-protein interactions, the UPS provides many opportunities for selective modulation of the pathway with small molecules. Here we discuss the principles that underlie the development of effective inhibitors or activators of the pathway. We emphasize insights from structural analysis and describe strategies for evaluating the selectivity of compounds. Nature Publishing Group US 2014-10-17 2014 /pmc/articles/PMC4639395/ /pubmed/25325686 http://dx.doi.org/10.1038/nchembio.1671 Text en © Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2014 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
King, Randall W
Finley, Daniel
Sculpting the proteome with small molecules
title Sculpting the proteome with small molecules
title_full Sculpting the proteome with small molecules
title_fullStr Sculpting the proteome with small molecules
title_full_unstemmed Sculpting the proteome with small molecules
title_short Sculpting the proteome with small molecules
title_sort sculpting the proteome with small molecules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639395/
https://www.ncbi.nlm.nih.gov/pubmed/25325686
http://dx.doi.org/10.1038/nchembio.1671
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