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Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins

Depression is a multicausal disorder and has been associated with metabolism regulation and immuno-inflammatory reaction. The anorectic molecule nesfatin-1 has recently been characterized as a potential mood regulator, but its precise effect on depression and the possible mechanisms remain unknown,...

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Autores principales: Ge, Jin-Fang, Xu, Ya-Yun, Qin, Gan, Peng, Yao-Nan, Zhang, Chao-Feng, Liu, Xing-Rui, Liang, Li-Chuan, Wang, Zhong-Zheng, Chen, Fei-Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639614/
https://www.ncbi.nlm.nih.gov/pubmed/26617482
http://dx.doi.org/10.3389/fnins.2015.00429
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author Ge, Jin-Fang
Xu, Ya-Yun
Qin, Gan
Peng, Yao-Nan
Zhang, Chao-Feng
Liu, Xing-Rui
Liang, Li-Chuan
Wang, Zhong-Zheng
Chen, Fei-Hu
author_facet Ge, Jin-Fang
Xu, Ya-Yun
Qin, Gan
Peng, Yao-Nan
Zhang, Chao-Feng
Liu, Xing-Rui
Liang, Li-Chuan
Wang, Zhong-Zheng
Chen, Fei-Hu
author_sort Ge, Jin-Fang
collection PubMed
description Depression is a multicausal disorder and has been associated with metabolism regulation and immuno-inflammatory reaction. The anorectic molecule nesfatin-1 has recently been characterized as a potential mood regulator, but its precise effect on depression and the possible mechanisms remain unknown, especially when given peripherally. In the present study, nesfatin-1 was intraperitoneally injected to the rats and the depression-like behavior and activity of the hypothalamic-pituitary-adrenal (HPA) axis were evaluated. The plasma concentrations of nesfatin-1, interleukin 6 (IL-6), and C-reactive protein (CRP); and the hypothalamic expression levels of nesfatin-1, synapsin I, and synaptotagmin I mRNA were evaluated in nesfatin-1 chronically treated rats. The results showed that both acute and chronic administration of nesfatin-1 increased immobility in the forced swimming test (FST), and resulted in the hyperactivity of HPA axis, as indicated by the increase of plasma corticosterone concentration and hypothalamic expression of corticotropin-releasing hormone (CRH) mRNA. Moreover, after chronic nesfatin-1 administration, the rats exhibited decreased activity and exploratory behavior in the open field test (OFT) and increased mRNA expression of synapsin I and synaptotagmin I in the hypothalamus. Furthermore, chronic administration of nesfatin-1 elevated plasma concentrations of IL-6 and CRP, which were positively correlated with despair behavior, plasma corticosterone level, and the hypothalamic mRNA expression of synapsin I and synaptotagmin I. These results indicated that exogenous nesfatin-1 could induce the immune-inflammatory activation, which might be a central hug linking the depression-like behavior and the imbalanced mRNA expression of synaptic vesicle proteins in the hypothalamus.
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spelling pubmed-46396142015-11-27 Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins Ge, Jin-Fang Xu, Ya-Yun Qin, Gan Peng, Yao-Nan Zhang, Chao-Feng Liu, Xing-Rui Liang, Li-Chuan Wang, Zhong-Zheng Chen, Fei-Hu Front Neurosci Endocrinology Depression is a multicausal disorder and has been associated with metabolism regulation and immuno-inflammatory reaction. The anorectic molecule nesfatin-1 has recently been characterized as a potential mood regulator, but its precise effect on depression and the possible mechanisms remain unknown, especially when given peripherally. In the present study, nesfatin-1 was intraperitoneally injected to the rats and the depression-like behavior and activity of the hypothalamic-pituitary-adrenal (HPA) axis were evaluated. The plasma concentrations of nesfatin-1, interleukin 6 (IL-6), and C-reactive protein (CRP); and the hypothalamic expression levels of nesfatin-1, synapsin I, and synaptotagmin I mRNA were evaluated in nesfatin-1 chronically treated rats. The results showed that both acute and chronic administration of nesfatin-1 increased immobility in the forced swimming test (FST), and resulted in the hyperactivity of HPA axis, as indicated by the increase of plasma corticosterone concentration and hypothalamic expression of corticotropin-releasing hormone (CRH) mRNA. Moreover, after chronic nesfatin-1 administration, the rats exhibited decreased activity and exploratory behavior in the open field test (OFT) and increased mRNA expression of synapsin I and synaptotagmin I in the hypothalamus. Furthermore, chronic administration of nesfatin-1 elevated plasma concentrations of IL-6 and CRP, which were positively correlated with despair behavior, plasma corticosterone level, and the hypothalamic mRNA expression of synapsin I and synaptotagmin I. These results indicated that exogenous nesfatin-1 could induce the immune-inflammatory activation, which might be a central hug linking the depression-like behavior and the imbalanced mRNA expression of synaptic vesicle proteins in the hypothalamus. Frontiers Media S.A. 2015-11-10 /pmc/articles/PMC4639614/ /pubmed/26617482 http://dx.doi.org/10.3389/fnins.2015.00429 Text en Copyright © 2015 Ge, Xu, Qin, Peng, Zhang, Liu, Liang, Wang and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ge, Jin-Fang
Xu, Ya-Yun
Qin, Gan
Peng, Yao-Nan
Zhang, Chao-Feng
Liu, Xing-Rui
Liang, Li-Chuan
Wang, Zhong-Zheng
Chen, Fei-Hu
Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins
title Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins
title_full Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins
title_fullStr Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins
title_full_unstemmed Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins
title_short Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins
title_sort depression-like behavior induced by nesfatin-1 in rats: involvement of increased immune activation and imbalance of synaptic vesicle proteins
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639614/
https://www.ncbi.nlm.nih.gov/pubmed/26617482
http://dx.doi.org/10.3389/fnins.2015.00429
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