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Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality
Objectives. To identify the risk factors that were associated with abandonment of treatment and mortality in tuberculosis (TB) patients. Methods. This study was a retrospective longitudinal cohort study involving tuberculosis patients treated between 2002 and 2008 in a TB reference center. Results....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639647/ https://www.ncbi.nlm.nih.gov/pubmed/26600948 http://dx.doi.org/10.1155/2015/546106 |
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author | Gomes, Nathália Mota de Faria Bastos, Meire Cardoso da Mota Marins, Renata Magliano Barbosa, Aline Alves Soares, Luiz Clóvis Parente de Abreu, Annelise Maria de Oliveira Wilken Souto Filho, João Tadeu Damian |
author_facet | Gomes, Nathália Mota de Faria Bastos, Meire Cardoso da Mota Marins, Renata Magliano Barbosa, Aline Alves Soares, Luiz Clóvis Parente de Abreu, Annelise Maria de Oliveira Wilken Souto Filho, João Tadeu Damian |
author_sort | Gomes, Nathália Mota de Faria |
collection | PubMed |
description | Objectives. To identify the risk factors that were associated with abandonment of treatment and mortality in tuberculosis (TB) patients. Methods. This study was a retrospective longitudinal cohort study involving tuberculosis patients treated between 2002 and 2008 in a TB reference center. Results. A total of 1,257 patients were evaluated, with 69.1% men, 54.4% under 40 years of age, 18.9% with extrapulmonary disease, and 9.3% coinfected with HIV. The risk factors that were associated with abandonment of treatment included male gender (OR = 2.05; 95% CI = 1.15–3.65) and nonadherence to previous treatment (OR = 3.14; 95% CI = 1.96–5.96). In addition, the presence of extrapulmonary TB was a protective factor (OR = 0.33, 95% CI = 0.14–0.76). The following risk factors were associated with mortality: age over 40 years (OR = 2.61, 95% CI = 1.76–3.85), coinfection with HIV (OR = 6.01, 95% CI = 3.78–9.56), illiteracy (OR = 1.88, 95% CI = 1.27–2.75), the presence of severe extrapulmonary TB (OR = 2.33, 95% CI = 1.24–4.38), and retreatment after relapse (OR = 1.95, 95% CI = 1.01–3.75). Conclusions. Male gender and retreatment after abandonment were independent risk factors for nonadherence to TB treatment. Furthermore, age over 40 years, coinfection with HIV, illiteracy, severe extrapulmonary TB, and retreatment after relapse were associated with higher TB mortality. Therefore, we suggest the implementation of direct measures that will control the identified risk factors to reduce the rates of treatment failure and TB-associated mortality. |
format | Online Article Text |
id | pubmed-4639647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46396472015-11-23 Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality Gomes, Nathália Mota de Faria Bastos, Meire Cardoso da Mota Marins, Renata Magliano Barbosa, Aline Alves Soares, Luiz Clóvis Parente de Abreu, Annelise Maria de Oliveira Wilken Souto Filho, João Tadeu Damian Pulm Med Research Article Objectives. To identify the risk factors that were associated with abandonment of treatment and mortality in tuberculosis (TB) patients. Methods. This study was a retrospective longitudinal cohort study involving tuberculosis patients treated between 2002 and 2008 in a TB reference center. Results. A total of 1,257 patients were evaluated, with 69.1% men, 54.4% under 40 years of age, 18.9% with extrapulmonary disease, and 9.3% coinfected with HIV. The risk factors that were associated with abandonment of treatment included male gender (OR = 2.05; 95% CI = 1.15–3.65) and nonadherence to previous treatment (OR = 3.14; 95% CI = 1.96–5.96). In addition, the presence of extrapulmonary TB was a protective factor (OR = 0.33, 95% CI = 0.14–0.76). The following risk factors were associated with mortality: age over 40 years (OR = 2.61, 95% CI = 1.76–3.85), coinfection with HIV (OR = 6.01, 95% CI = 3.78–9.56), illiteracy (OR = 1.88, 95% CI = 1.27–2.75), the presence of severe extrapulmonary TB (OR = 2.33, 95% CI = 1.24–4.38), and retreatment after relapse (OR = 1.95, 95% CI = 1.01–3.75). Conclusions. Male gender and retreatment after abandonment were independent risk factors for nonadherence to TB treatment. Furthermore, age over 40 years, coinfection with HIV, illiteracy, severe extrapulmonary TB, and retreatment after relapse were associated with higher TB mortality. Therefore, we suggest the implementation of direct measures that will control the identified risk factors to reduce the rates of treatment failure and TB-associated mortality. Hindawi Publishing Corporation 2015 2015-10-27 /pmc/articles/PMC4639647/ /pubmed/26600948 http://dx.doi.org/10.1155/2015/546106 Text en Copyright © 2015 Nathália Mota de Faria Gomes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gomes, Nathália Mota de Faria Bastos, Meire Cardoso da Mota Marins, Renata Magliano Barbosa, Aline Alves Soares, Luiz Clóvis Parente de Abreu, Annelise Maria de Oliveira Wilken Souto Filho, João Tadeu Damian Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality |
title | Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality |
title_full | Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality |
title_fullStr | Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality |
title_full_unstemmed | Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality |
title_short | Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality |
title_sort | differences between risk factors associated with tuberculosis treatment abandonment and mortality |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639647/ https://www.ncbi.nlm.nih.gov/pubmed/26600948 http://dx.doi.org/10.1155/2015/546106 |
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