Cargando…

High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma

Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyr...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Jing, Yu, Zhenqian, Guan, Haixia, Shi, Liangfeng, Liu, Yongping, Zhao, Na, Shan, Zhongyan, Han, Cheng, Li, Yushu, Teng, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639663/
https://www.ncbi.nlm.nih.gov/pubmed/26600670
http://dx.doi.org/10.1155/2015/648670
_version_ 1782399960319262720
author Qin, Jing
Yu, Zhenqian
Guan, Haixia
Shi, Liangfeng
Liu, Yongping
Zhao, Na
Shan, Zhongyan
Han, Cheng
Li, Yushu
Teng, Weiping
author_facet Qin, Jing
Yu, Zhenqian
Guan, Haixia
Shi, Liangfeng
Liu, Yongping
Zhao, Na
Shan, Zhongyan
Han, Cheng
Li, Yushu
Teng, Weiping
author_sort Qin, Jing
collection PubMed
description Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery. Methods. Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated. Thyroid autoimmunity was assessed by the presence of thyroglobulin (TgAb) or thyroid peroxidase antibodies (TPOAb). Results. Among our study cohort, the prevalence of elevated TgAb (≥40 IU/mL) and TPOAb (≥50 IU/mL) was higher in patients with DTC than those with benign nodules. Patients with DTC and elevated TgAb had a higher prevalence of extrathyroidal invasion. In the multivariate analysis, TgAb ≥ 40 IU/mL was significantly associated with DTC (odds ratio [OR] = 2.10, 95% confidence interval [CI] 1.40–3.15) compared with TgAb < 40 IU/mL group, independent of other confounding factors such as decreased age, single nodule, and elevated TSH level. In conclusion, elevated TgAb was associated with DTC. Conclusions. This study revealed that high levels of TgAb may act as an independent prediction factor for DTC, and suggests that patients with high TgAb concentrations may be predisposed to DTC.
format Online
Article
Text
id pubmed-4639663
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-46396632015-11-23 High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma Qin, Jing Yu, Zhenqian Guan, Haixia Shi, Liangfeng Liu, Yongping Zhao, Na Shan, Zhongyan Han, Cheng Li, Yushu Teng, Weiping Dis Markers Research Article Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery. Methods. Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated. Thyroid autoimmunity was assessed by the presence of thyroglobulin (TgAb) or thyroid peroxidase antibodies (TPOAb). Results. Among our study cohort, the prevalence of elevated TgAb (≥40 IU/mL) and TPOAb (≥50 IU/mL) was higher in patients with DTC than those with benign nodules. Patients with DTC and elevated TgAb had a higher prevalence of extrathyroidal invasion. In the multivariate analysis, TgAb ≥ 40 IU/mL was significantly associated with DTC (odds ratio [OR] = 2.10, 95% confidence interval [CI] 1.40–3.15) compared with TgAb < 40 IU/mL group, independent of other confounding factors such as decreased age, single nodule, and elevated TSH level. In conclusion, elevated TgAb was associated with DTC. Conclusions. This study revealed that high levels of TgAb may act as an independent prediction factor for DTC, and suggests that patients with high TgAb concentrations may be predisposed to DTC. Hindawi Publishing Corporation 2015 2015-10-27 /pmc/articles/PMC4639663/ /pubmed/26600670 http://dx.doi.org/10.1155/2015/648670 Text en Copyright © 2015 Jing Qin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qin, Jing
Yu, Zhenqian
Guan, Haixia
Shi, Liangfeng
Liu, Yongping
Zhao, Na
Shan, Zhongyan
Han, Cheng
Li, Yushu
Teng, Weiping
High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
title High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
title_full High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
title_fullStr High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
title_full_unstemmed High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
title_short High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
title_sort high thyroglobulin antibody levels increase the risk of differentiated thyroid carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639663/
https://www.ncbi.nlm.nih.gov/pubmed/26600670
http://dx.doi.org/10.1155/2015/648670
work_keys_str_mv AT qinjing highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT yuzhenqian highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT guanhaixia highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT shiliangfeng highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT liuyongping highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT zhaona highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT shanzhongyan highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT hancheng highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT liyushu highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma
AT tengweiping highthyroglobulinantibodylevelsincreasetheriskofdifferentiatedthyroidcarcinoma