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High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma
Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639663/ https://www.ncbi.nlm.nih.gov/pubmed/26600670 http://dx.doi.org/10.1155/2015/648670 |
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author | Qin, Jing Yu, Zhenqian Guan, Haixia Shi, Liangfeng Liu, Yongping Zhao, Na Shan, Zhongyan Han, Cheng Li, Yushu Teng, Weiping |
author_facet | Qin, Jing Yu, Zhenqian Guan, Haixia Shi, Liangfeng Liu, Yongping Zhao, Na Shan, Zhongyan Han, Cheng Li, Yushu Teng, Weiping |
author_sort | Qin, Jing |
collection | PubMed |
description | Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery. Methods. Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated. Thyroid autoimmunity was assessed by the presence of thyroglobulin (TgAb) or thyroid peroxidase antibodies (TPOAb). Results. Among our study cohort, the prevalence of elevated TgAb (≥40 IU/mL) and TPOAb (≥50 IU/mL) was higher in patients with DTC than those with benign nodules. Patients with DTC and elevated TgAb had a higher prevalence of extrathyroidal invasion. In the multivariate analysis, TgAb ≥ 40 IU/mL was significantly associated with DTC (odds ratio [OR] = 2.10, 95% confidence interval [CI] 1.40–3.15) compared with TgAb < 40 IU/mL group, independent of other confounding factors such as decreased age, single nodule, and elevated TSH level. In conclusion, elevated TgAb was associated with DTC. Conclusions. This study revealed that high levels of TgAb may act as an independent prediction factor for DTC, and suggests that patients with high TgAb concentrations may be predisposed to DTC. |
format | Online Article Text |
id | pubmed-4639663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46396632015-11-23 High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma Qin, Jing Yu, Zhenqian Guan, Haixia Shi, Liangfeng Liu, Yongping Zhao, Na Shan, Zhongyan Han, Cheng Li, Yushu Teng, Weiping Dis Markers Research Article Background. Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. Objective. To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained from patients who underwent thyroid surgery. Methods. Data of thyroid nodules obtained from 1,638 patients who underwent thyroid surgery were evaluated. Thyroid autoimmunity was assessed by the presence of thyroglobulin (TgAb) or thyroid peroxidase antibodies (TPOAb). Results. Among our study cohort, the prevalence of elevated TgAb (≥40 IU/mL) and TPOAb (≥50 IU/mL) was higher in patients with DTC than those with benign nodules. Patients with DTC and elevated TgAb had a higher prevalence of extrathyroidal invasion. In the multivariate analysis, TgAb ≥ 40 IU/mL was significantly associated with DTC (odds ratio [OR] = 2.10, 95% confidence interval [CI] 1.40–3.15) compared with TgAb < 40 IU/mL group, independent of other confounding factors such as decreased age, single nodule, and elevated TSH level. In conclusion, elevated TgAb was associated with DTC. Conclusions. This study revealed that high levels of TgAb may act as an independent prediction factor for DTC, and suggests that patients with high TgAb concentrations may be predisposed to DTC. Hindawi Publishing Corporation 2015 2015-10-27 /pmc/articles/PMC4639663/ /pubmed/26600670 http://dx.doi.org/10.1155/2015/648670 Text en Copyright © 2015 Jing Qin et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Qin, Jing Yu, Zhenqian Guan, Haixia Shi, Liangfeng Liu, Yongping Zhao, Na Shan, Zhongyan Han, Cheng Li, Yushu Teng, Weiping High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma |
title | High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma |
title_full | High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma |
title_fullStr | High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma |
title_full_unstemmed | High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma |
title_short | High Thyroglobulin Antibody Levels Increase the Risk of Differentiated Thyroid Carcinoma |
title_sort | high thyroglobulin antibody levels increase the risk of differentiated thyroid carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639663/ https://www.ncbi.nlm.nih.gov/pubmed/26600670 http://dx.doi.org/10.1155/2015/648670 |
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