Cargando…

The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research

The objective of this study is to assess whether statin use is associated with beneficial effects on COPD outcomes. We conducted a systematic review and meta-analysis of all available studies describing the association between statin use and COPD mortality, exacerbations and cardiovascular events. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Chao, Wu, Yinfang, Xu, Zhiwei, Lv, Dan, Zhang, Chao, Lai, Tianwen, Li, Wen, Shen, Huahao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639730/
https://www.ncbi.nlm.nih.gov/pubmed/26553965
http://dx.doi.org/10.1038/srep16461
_version_ 1782399972925243392
author Cao, Chao
Wu, Yinfang
Xu, Zhiwei
Lv, Dan
Zhang, Chao
Lai, Tianwen
Li, Wen
Shen, Huahao
author_facet Cao, Chao
Wu, Yinfang
Xu, Zhiwei
Lv, Dan
Zhang, Chao
Lai, Tianwen
Li, Wen
Shen, Huahao
author_sort Cao, Chao
collection PubMed
description The objective of this study is to assess whether statin use is associated with beneficial effects on COPD outcomes. We conducted a systematic review and meta-analysis of all available studies describing the association between statin use and COPD mortality, exacerbations and cardiovascular events. Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched, with no restrictions. The hazard ratio (HR) with 95% confidence interval (CI) was estimated. Fifteen studies with a total of 238,459 patients were included. Nine articles provided data on all-cause mortality (124,543 participants), and they gave a HR of 0.62 (95% CI 0.52 to 0.73). Three studies provided data on cancer mortality (90,077 participants), HR 0.83 (0.65 to 1.08); four studies on COPD mortality (88,767 participants), HR 0.48 (0.23 to 0.99); and three studies on cardiovascular mortality (90,041 participants), HR 0.93 (0.50 to 1.72). Six articles provided data on COPD exacerbation with or without hospitalization (129,796 participants), HR 0.64 (0.55 to 0.75). Additionally, the use of statins was associated with a significant reduction risk of myocardial infarction, but not for stroke. Our systematic review showed a clear benefit of statins in patients with COPD.
format Online
Article
Text
id pubmed-4639730
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-46397302015-12-02 The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research Cao, Chao Wu, Yinfang Xu, Zhiwei Lv, Dan Zhang, Chao Lai, Tianwen Li, Wen Shen, Huahao Sci Rep Article The objective of this study is to assess whether statin use is associated with beneficial effects on COPD outcomes. We conducted a systematic review and meta-analysis of all available studies describing the association between statin use and COPD mortality, exacerbations and cardiovascular events. Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched, with no restrictions. The hazard ratio (HR) with 95% confidence interval (CI) was estimated. Fifteen studies with a total of 238,459 patients were included. Nine articles provided data on all-cause mortality (124,543 participants), and they gave a HR of 0.62 (95% CI 0.52 to 0.73). Three studies provided data on cancer mortality (90,077 participants), HR 0.83 (0.65 to 1.08); four studies on COPD mortality (88,767 participants), HR 0.48 (0.23 to 0.99); and three studies on cardiovascular mortality (90,041 participants), HR 0.93 (0.50 to 1.72). Six articles provided data on COPD exacerbation with or without hospitalization (129,796 participants), HR 0.64 (0.55 to 0.75). Additionally, the use of statins was associated with a significant reduction risk of myocardial infarction, but not for stroke. Our systematic review showed a clear benefit of statins in patients with COPD. Nature Publishing Group 2015-11-10 /pmc/articles/PMC4639730/ /pubmed/26553965 http://dx.doi.org/10.1038/srep16461 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Cao, Chao
Wu, Yinfang
Xu, Zhiwei
Lv, Dan
Zhang, Chao
Lai, Tianwen
Li, Wen
Shen, Huahao
The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research
title The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research
title_full The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research
title_fullStr The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research
title_full_unstemmed The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research
title_short The effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research
title_sort effect of statins on chronic obstructive pulmonary disease exacerbation and mortality: a systematic review and meta-analysis of observational research
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639730/
https://www.ncbi.nlm.nih.gov/pubmed/26553965
http://dx.doi.org/10.1038/srep16461
work_keys_str_mv AT caochao theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT wuyinfang theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT xuzhiwei theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT lvdan theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT zhangchao theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT laitianwen theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT liwen theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT shenhuahao theeffectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT caochao effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT wuyinfang effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT xuzhiwei effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT lvdan effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT zhangchao effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT laitianwen effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT liwen effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch
AT shenhuahao effectofstatinsonchronicobstructivepulmonarydiseaseexacerbationandmortalityasystematicreviewandmetaanalysisofobservationalresearch