Mice lacking the PSD-95–interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning

Protein ubiquitination has a significant influence on diverse aspects of neuronal development and function. Dorfin, also known as Rnf19a, is a RING finger E3 ubiquitin ligase implicated in amyotrophic lateral sclerosis and Parkinson’s disease, but its in vivo functions have not been explored. We rep...

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Detalles Bibliográficos
Autores principales: Park, Hanwool, Yang, Jinhee, Kim, Ryunhee, Li, Yan, Lee, Yeunkum, Lee, Chungwoo, Park, Jongil, Lee, Dongmin, Kim, Hyun, Kim, Eunjoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639748/
https://www.ncbi.nlm.nih.gov/pubmed/26553645
http://dx.doi.org/10.1038/srep16410

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