Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

Insufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made in regulating insulin secretion from β-cells in diabetic patients, no pharmacological agents have been described that increase β-cell replication in humans. Here we report aminopyra...

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Detalles Bibliográficos
Autores principales: Shen, Weijun, Taylor, Brandon, Jin, Qihui, Nguyen-Tran, Van, Meeusen, Shelly, Zhang, You-Qing, Kamireddy, Anwesh, Swafford, Austin, Powers, Andrew F., Walker, John, Lamb, John, Bursalaya, Badry, DiDonato, Michael, Harb, George, Qiu, Minhua, Filippi, Christophe M., Deaton, Lisa, Turk, Carolina N., Suarez-Pinzon, Wilma L., Liu, Yahu, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Li, Jing, Herman, Ann E., Hering, Bernhard J., Wu, Tom, Martin Seidel, H., McNamara, Peter, Glynne, Richard, Laffitte, Bryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639830/
https://www.ncbi.nlm.nih.gov/pubmed/26496802
http://dx.doi.org/10.1038/ncomms9372

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