Adaptation of H9N2 AIV in guinea pigs enables efficient transmission by direct contact and inefficient transmission by respiratory droplets

H9N2 avian influenza viruses circulate worldwide in poultry and have sporadically infected humans, raising concern whether H9N2 viruses have pandemic potential. Here, we use a guinea pig model to examine whether serial passage results in adaptive viral changes that confer a transmissible phenotype t...

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Detalles Bibliográficos
Autores principales: Sang, Xiaoyu, Wang, Airong, Ding, Jie, Kong, Huihui, Gao, Xiaolong, Li, Lin, Chai, Tongjie, Li, Yuanguo, Zhang, Kun, Wang, Chengyu, Wan, Zhonghai, Huang, Geng, Wang, Tiecheng, Feng, Na, Zheng, Xuexing, Wang, Hualei, Zhao, Yongkun, Yang, Songtao, Qian, Jun, Hu, Guixue, Gao, Yuwei, Xia, Xianzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639850/
https://www.ncbi.nlm.nih.gov/pubmed/26552719
http://dx.doi.org/10.1038/srep15928

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