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Bub3–BubR1-dependent sequestration of Cdc20(Fizzy) at DNA breaks facilitates the correct segregation of broken chromosomes
The presence of DNA double-strand breaks during mitosis is particularly challenging for the cell, as it produces broken chromosomes lacking a centromere. This situation can cause genomic instability resulting from improper segregation of the broken fragments into daughter cells. We recently uncovere...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639866/ https://www.ncbi.nlm.nih.gov/pubmed/26553926 http://dx.doi.org/10.1083/jcb.201504059 |