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TRIP13(PCH-2) promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response

The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset. Yet, whether additional factors contribute to Mad2’s kinetochore localization remains unclea...

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Detalles Bibliográficos
Autores principales:	Nelson, Christian R., Hwang, Tom, Chen, Pin-Hsi, Bhalla, Needhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639874/ https://www.ncbi.nlm.nih.gov/pubmed/26527744 http://dx.doi.org/10.1083/jcb.201505114

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