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Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases
PURPOSE: To evaluate early perfusion changes in normal tissue following stereotactic radiosurgery (SRS). METHODS: Nineteen patients harboring twenty-two brain metastases treated with SRS were imaged with dynamic susceptibility magnetic resonance imaging (DSC MRI) at baseline, 1 week and 1 month post...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639904/ https://www.ncbi.nlm.nih.gov/pubmed/26269612 http://dx.doi.org/10.7785/tcrtexpress.2013.600279 |
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author | Jakubovic, Raphael Sahgal, Arjun Ruschin, Mark Pejović-Milić, Ana Milwid, Rachael Aviv, Richard I. |
author_facet | Jakubovic, Raphael Sahgal, Arjun Ruschin, Mark Pejović-Milić, Ana Milwid, Rachael Aviv, Richard I. |
author_sort | Jakubovic, Raphael |
collection | PubMed |
description | PURPOSE: To evaluate early perfusion changes in normal tissue following stereotactic radiosurgery (SRS). METHODS: Nineteen patients harboring twenty-two brain metastases treated with SRS were imaged with dynamic susceptibility magnetic resonance imaging (DSC MRI) at baseline, 1 week and 1 month post SRS. Relative cerebral blood volume and flow (rCBV and rCBF) ratios were evaluated outside of tumor within a combined region of interest (ROI) and separately within gray matter (GM) and white matter (WM) ROIs. Three-dimensional dose distribution from each SRS plan was divided into six regions: (1) <2 Gy; (2) 2-5 Gy; (3) 5-10 Gy; (4) 10-12 Gy; (5) 12-16 Gy; and (6) >16 Gy. rCBV and rCBF ratio differences between baseline, 1 week and 1 month were compared. Best linear fit plots quantified normal tissue dose-dependency. RESULTS: Significant rCBV ratio increases were present between baseline and 1 month for all ROIs and dose ranges except for WM ROI receiving <2 Gy. rCBV ratio for all ROIs was maximally increased from baseline to 1 month with the greatest changes occurring within the 5-10 Gy dose range (53.1%). rCBF ratio was maximally increased from baseline to 1 month for all ROIs within the 5-10 Gy dose range (33.9-45.0%). Both rCBV and rCBF ratios were most elevated within GM ROIs. A weak, positive but not significant association between dose, rCBV and rCBF ratio was demonstrated. Progressive rCBV and rCBF ratio increased with dose up to 10 Gy at 1 month. CONCLUSION: Normal tissue response following SRS can be characterized by dose, tissue, and time specific increases in rCBV and rCBF ratio. |
format | Online Article Text |
id | pubmed-4639904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-46399042015-12-01 Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases Jakubovic, Raphael Sahgal, Arjun Ruschin, Mark Pejović-Milić, Ana Milwid, Rachael Aviv, Richard I. Technol Cancer Res Treat Original Articles PURPOSE: To evaluate early perfusion changes in normal tissue following stereotactic radiosurgery (SRS). METHODS: Nineteen patients harboring twenty-two brain metastases treated with SRS were imaged with dynamic susceptibility magnetic resonance imaging (DSC MRI) at baseline, 1 week and 1 month post SRS. Relative cerebral blood volume and flow (rCBV and rCBF) ratios were evaluated outside of tumor within a combined region of interest (ROI) and separately within gray matter (GM) and white matter (WM) ROIs. Three-dimensional dose distribution from each SRS plan was divided into six regions: (1) <2 Gy; (2) 2-5 Gy; (3) 5-10 Gy; (4) 10-12 Gy; (5) 12-16 Gy; and (6) >16 Gy. rCBV and rCBF ratio differences between baseline, 1 week and 1 month were compared. Best linear fit plots quantified normal tissue dose-dependency. RESULTS: Significant rCBV ratio increases were present between baseline and 1 month for all ROIs and dose ranges except for WM ROI receiving <2 Gy. rCBV ratio for all ROIs was maximally increased from baseline to 1 month with the greatest changes occurring within the 5-10 Gy dose range (53.1%). rCBF ratio was maximally increased from baseline to 1 month for all ROIs within the 5-10 Gy dose range (33.9-45.0%). Both rCBV and rCBF ratios were most elevated within GM ROIs. A weak, positive but not significant association between dose, rCBV and rCBF ratio was demonstrated. Progressive rCBV and rCBF ratio increased with dose up to 10 Gy at 1 month. CONCLUSION: Normal tissue response following SRS can be characterized by dose, tissue, and time specific increases in rCBV and rCBF ratio. SAGE Publications 2015-08 /pmc/articles/PMC4639904/ /pubmed/26269612 http://dx.doi.org/10.7785/tcrtexpress.2013.600279 Text en © The Author(s) 2014 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Jakubovic, Raphael Sahgal, Arjun Ruschin, Mark Pejović-Milić, Ana Milwid, Rachael Aviv, Richard I. Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases |
title | Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases |
title_full | Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases |
title_fullStr | Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases |
title_full_unstemmed | Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases |
title_short | Non Tumor Perfusion Changes Following Stereotactic Radiosurgery to Brain Metastases |
title_sort | non tumor perfusion changes following stereotactic radiosurgery to brain metastases |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639904/ https://www.ncbi.nlm.nih.gov/pubmed/26269612 http://dx.doi.org/10.7785/tcrtexpress.2013.600279 |
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