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Magnetotactic molecular architectures from self-assembly of β-peptide foldamers

The design of stimuli-responsive self-assembled molecular systems capable of undergoing mechanical work is one of the most important challenges in synthetic chemistry and materials science. Here we report that foldectures, that is, self-assembled molecular architectures of β-peptide foldamers, unifo...

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Autores principales: Kwon, Sunbum, Kim, Beom Jin, Lim, Hyung-Kyu, Kang, Kyungtae, Yoo, Sung Hyun, Gong, Jintaek, Yoon, Eunyoung, Lee, Juno, Choi, Insung S., Kim, Hyungjun, Lee, Hee-Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640081/
https://www.ncbi.nlm.nih.gov/pubmed/26510658
http://dx.doi.org/10.1038/ncomms9747
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author Kwon, Sunbum
Kim, Beom Jin
Lim, Hyung-Kyu
Kang, Kyungtae
Yoo, Sung Hyun
Gong, Jintaek
Yoon, Eunyoung
Lee, Juno
Choi, Insung S.
Kim, Hyungjun
Lee, Hee-Seung
author_facet Kwon, Sunbum
Kim, Beom Jin
Lim, Hyung-Kyu
Kang, Kyungtae
Yoo, Sung Hyun
Gong, Jintaek
Yoon, Eunyoung
Lee, Juno
Choi, Insung S.
Kim, Hyungjun
Lee, Hee-Seung
author_sort Kwon, Sunbum
collection PubMed
description The design of stimuli-responsive self-assembled molecular systems capable of undergoing mechanical work is one of the most important challenges in synthetic chemistry and materials science. Here we report that foldectures, that is, self-assembled molecular architectures of β-peptide foldamers, uniformly align with respect to an applied static magnetic field, and also show instantaneous orientational motion in a dynamic magnetic field. This response is explained by the amplified anisotropy of the diamagnetic susceptibilities as a result of the well-ordered molecular packing of the foldectures. In addition, the motions of foldectures at the microscale can be translated into magnetotactic behaviour at the macroscopic scale in a way reminiscent to that of magnetosomes in magnetotactic bacteria. This study will provide significant inspiration for designing the next generation of biocompatible peptide-based molecular machines with applications in biological systems.
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spelling pubmed-46400812015-12-08 Magnetotactic molecular architectures from self-assembly of β-peptide foldamers Kwon, Sunbum Kim, Beom Jin Lim, Hyung-Kyu Kang, Kyungtae Yoo, Sung Hyun Gong, Jintaek Yoon, Eunyoung Lee, Juno Choi, Insung S. Kim, Hyungjun Lee, Hee-Seung Nat Commun Article The design of stimuli-responsive self-assembled molecular systems capable of undergoing mechanical work is one of the most important challenges in synthetic chemistry and materials science. Here we report that foldectures, that is, self-assembled molecular architectures of β-peptide foldamers, uniformly align with respect to an applied static magnetic field, and also show instantaneous orientational motion in a dynamic magnetic field. This response is explained by the amplified anisotropy of the diamagnetic susceptibilities as a result of the well-ordered molecular packing of the foldectures. In addition, the motions of foldectures at the microscale can be translated into magnetotactic behaviour at the macroscopic scale in a way reminiscent to that of magnetosomes in magnetotactic bacteria. This study will provide significant inspiration for designing the next generation of biocompatible peptide-based molecular machines with applications in biological systems. Nature Pub. Group 2015-10-29 /pmc/articles/PMC4640081/ /pubmed/26510658 http://dx.doi.org/10.1038/ncomms9747 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Kwon, Sunbum
Kim, Beom Jin
Lim, Hyung-Kyu
Kang, Kyungtae
Yoo, Sung Hyun
Gong, Jintaek
Yoon, Eunyoung
Lee, Juno
Choi, Insung S.
Kim, Hyungjun
Lee, Hee-Seung
Magnetotactic molecular architectures from self-assembly of β-peptide foldamers
title Magnetotactic molecular architectures from self-assembly of β-peptide foldamers
title_full Magnetotactic molecular architectures from self-assembly of β-peptide foldamers
title_fullStr Magnetotactic molecular architectures from self-assembly of β-peptide foldamers
title_full_unstemmed Magnetotactic molecular architectures from self-assembly of β-peptide foldamers
title_short Magnetotactic molecular architectures from self-assembly of β-peptide foldamers
title_sort magnetotactic molecular architectures from self-assembly of β-peptide foldamers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640081/
https://www.ncbi.nlm.nih.gov/pubmed/26510658
http://dx.doi.org/10.1038/ncomms9747
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