Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

The antiviral activity of nucleoside reverse transcriptase inhibitors is often limited by ineffective phosphorylation. We report on a nucleoside triphosphate (NTP) prodrug approach in which the γ-phosphate of NTPs is bioreversibly modified. A series of TriPPPro-compounds bearing two lipophilic maski...

Descripción completa

Detalles Bibliográficos
Autores principales: Gollnest, Tristan, de Oliveira, Thiago Dinis, Schols, Dominique, Balzarini, Jan, Meier, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640093/
https://www.ncbi.nlm.nih.gov/pubmed/26503889
http://dx.doi.org/10.1038/ncomms9716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640093/
https://www.ncbi.nlm.nih.gov/pubmed/26503889
http://dx.doi.org/10.1038/ncomms9716

Ejemplares similares