A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression

BACKGROUND: To facilitate indefinite proliferation, stem cells and most cancer cells require the activity of telomerase, which counteracts the successive shortening of telomeres caused by incomplete DNA replication at the very end of each chromosome. Human telomerase activity is often determined by...

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Detalles Bibliográficos
Autores principales: Xi, Linghe, Schmidt, Jens C., Zaug, Arthur J., Ascarrunz, Dante R., Cech, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640169/
https://www.ncbi.nlm.nih.gov/pubmed/26553065
http://dx.doi.org/10.1186/s13059-015-0791-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640169/
https://www.ncbi.nlm.nih.gov/pubmed/26553065
http://dx.doi.org/10.1186/s13059-015-0791-1

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