Cargando…

Allergen Immunotherapy (AIT): a prototype of Precision Medicine

Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to...

Descripción completa

Detalles Bibliográficos
Autores principales: Canonica, GW, Bachert, C., Hellings, P., Ryan, D., Valovirta, E., Wickman, M., De Beaumont, O., Bousquet, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640346/
https://www.ncbi.nlm.nih.gov/pubmed/26594303
http://dx.doi.org/10.1186/s40413-015-0079-7
_version_ 1782400056630968320
author Canonica, GW
Bachert, C.
Hellings, P.
Ryan, D.
Valovirta, E.
Wickman, M.
De Beaumont, O.
Bousquet, J.
author_facet Canonica, GW
Bachert, C.
Hellings, P.
Ryan, D.
Valovirta, E.
Wickman, M.
De Beaumont, O.
Bousquet, J.
author_sort Canonica, GW
collection PubMed
description Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to the specific IgE spectrum of an individual and modifies the natural course of the disease as it has a persistent efficacy after completion of treatment. In this perspective Allergen Immunotherapy - AIT has to be presently considered a prototype of Precision Medicine. Precise information and biomarkers provided by systems medicine and network medicine will address the discovery of Allergen immunotherapy biomarkers for (i) identification of the causes, (ii) stratification of eligible patients for AIT and (iii) the assessment of AIT efficacy. This area of medical technology is evolving rapidly and, compelemented by e-health, will change the way we practice medicine. It will help to monitor patients’ disease control and data for (i) patient stratification, (ii) clinical trials, (iii) monitoring the efficacy and safety of targeted therapies which are critical for reaching an appropriate reimbursement. Biomarkers associated with e-health combined with a clinical decision support system (CDSS) will change the scope of Allergen immunotherapy. The cost/effectiveness of Allergen immunotherapy is a key issue for successful implementation. It should include the long-term benefits in the pharmaco-economic evaluation, since no other allergy treatment has this specific characteristic. AIT is the prototype of current and future precision medicine.
format Online
Article
Text
id pubmed-4640346
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-46403462015-11-20 Allergen Immunotherapy (AIT): a prototype of Precision Medicine Canonica, GW Bachert, C. Hellings, P. Ryan, D. Valovirta, E. Wickman, M. De Beaumont, O. Bousquet, J. World Allergy Organ J Review Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to the specific IgE spectrum of an individual and modifies the natural course of the disease as it has a persistent efficacy after completion of treatment. In this perspective Allergen Immunotherapy - AIT has to be presently considered a prototype of Precision Medicine. Precise information and biomarkers provided by systems medicine and network medicine will address the discovery of Allergen immunotherapy biomarkers for (i) identification of the causes, (ii) stratification of eligible patients for AIT and (iii) the assessment of AIT efficacy. This area of medical technology is evolving rapidly and, compelemented by e-health, will change the way we practice medicine. It will help to monitor patients’ disease control and data for (i) patient stratification, (ii) clinical trials, (iii) monitoring the efficacy and safety of targeted therapies which are critical for reaching an appropriate reimbursement. Biomarkers associated with e-health combined with a clinical decision support system (CDSS) will change the scope of Allergen immunotherapy. The cost/effectiveness of Allergen immunotherapy is a key issue for successful implementation. It should include the long-term benefits in the pharmaco-economic evaluation, since no other allergy treatment has this specific characteristic. AIT is the prototype of current and future precision medicine. BioMed Central 2015-11-10 /pmc/articles/PMC4640346/ /pubmed/26594303 http://dx.doi.org/10.1186/s40413-015-0079-7 Text en © Canonica et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Canonica, GW
Bachert, C.
Hellings, P.
Ryan, D.
Valovirta, E.
Wickman, M.
De Beaumont, O.
Bousquet, J.
Allergen Immunotherapy (AIT): a prototype of Precision Medicine
title Allergen Immunotherapy (AIT): a prototype of Precision Medicine
title_full Allergen Immunotherapy (AIT): a prototype of Precision Medicine
title_fullStr Allergen Immunotherapy (AIT): a prototype of Precision Medicine
title_full_unstemmed Allergen Immunotherapy (AIT): a prototype of Precision Medicine
title_short Allergen Immunotherapy (AIT): a prototype of Precision Medicine
title_sort allergen immunotherapy (ait): a prototype of precision medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640346/
https://www.ncbi.nlm.nih.gov/pubmed/26594303
http://dx.doi.org/10.1186/s40413-015-0079-7
work_keys_str_mv AT canonicagw allergenimmunotherapyaitaprototypeofprecisionmedicine
AT bachertc allergenimmunotherapyaitaprototypeofprecisionmedicine
AT hellingsp allergenimmunotherapyaitaprototypeofprecisionmedicine
AT ryand allergenimmunotherapyaitaprototypeofprecisionmedicine
AT valovirtae allergenimmunotherapyaitaprototypeofprecisionmedicine
AT wickmanm allergenimmunotherapyaitaprototypeofprecisionmedicine
AT debeaumonto allergenimmunotherapyaitaprototypeofprecisionmedicine
AT bousquetj allergenimmunotherapyaitaprototypeofprecisionmedicine