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Linalool oxide: generalist plant based lure for mosquito disease vectors

BACKGROUND: Lack of effective vaccines and therapeutics for important arboviral diseases such as Rift Valley fever (RVF) and dengue, necessitates continuous monitoring of vector populations for infections in them. Plant-based lures as surveillance tools has the potential of targeting mosquitoes of b...

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Autores principales: Nyasembe, Vincent O., Tchouassi, David P., Mbogo, Charles M., Sole, Catherine L., Pirk, Christian, Torto, Baldwyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640417/
https://www.ncbi.nlm.nih.gov/pubmed/26552398
http://dx.doi.org/10.1186/s13071-015-1184-8
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author Nyasembe, Vincent O.
Tchouassi, David P.
Mbogo, Charles M.
Sole, Catherine L.
Pirk, Christian
Torto, Baldwyn
author_facet Nyasembe, Vincent O.
Tchouassi, David P.
Mbogo, Charles M.
Sole, Catherine L.
Pirk, Christian
Torto, Baldwyn
author_sort Nyasembe, Vincent O.
collection PubMed
description BACKGROUND: Lack of effective vaccines and therapeutics for important arboviral diseases such as Rift Valley fever (RVF) and dengue, necessitates continuous monitoring of vector populations for infections in them. Plant-based lures as surveillance tools has the potential of targeting mosquitoes of both sexes and females of varied physiological states; yet such lures are lacking for vectors of these diseases. Here, we present evidence of the effectiveness of linalool oxide (LO), a single plant-based lure previously developed for malaria vectors in trapping RVF vectors, Aedes mcintoshi and Aedes ochraceus, and dengue vector, Aedes aegypti. METHODS: For RVF vectors, we used CDC traps to evaluate the performance of LO against three vertebrate-based lures: CO(2) (dry ice), BioGent (BG) lure, and HONAD (a blend of aldehydes) in 2 experiments with Completely Randomized design: 1) using unlit CDC traps baited separately with LO, HONAD and BG-lure, and unlit CDC trap + CO(2) and lit CDC trap as controls, 2) similar treatments but with inclusion of CO(2) to all the traps. For dengue vectors, LO was evaluated against BG lure using BG sentinel traps, in a 3 × 6 Latin Square design, first as single lures and then combined with CO(2) and traps baited with CO(2) included as controls. Trap captures were compared between the treatments using Chi square and GLM. RESULTS: Low captures of RVF vectors were recorded for all lures in the absence of CO(2) with no significant difference between them. When combined with CO(2), LO performance in trapping these vectors was comparable to BG-lure and HONAD but it was less effective than the lit CDC trap. In the absence of CO(2), LO performed comparably with the BG-lure in trapping female Ae. aegypti, but with significantly higher males recorded in traps baited with the plant-based lure. When CO(2) was added, LO was significantly better than the BG-lure with a 2.8- fold increase in captures of male Ae. aegypti. CONCLUSIONS: These results highlight the potential of LO as a generalist plant-based lure for mosquito disease vectors, pending further assessment of possible specificity in their response profile to the different stereoisomers of this compound. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-015-1184-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-46404172015-11-11 Linalool oxide: generalist plant based lure for mosquito disease vectors Nyasembe, Vincent O. Tchouassi, David P. Mbogo, Charles M. Sole, Catherine L. Pirk, Christian Torto, Baldwyn Parasit Vectors Research BACKGROUND: Lack of effective vaccines and therapeutics for important arboviral diseases such as Rift Valley fever (RVF) and dengue, necessitates continuous monitoring of vector populations for infections in them. Plant-based lures as surveillance tools has the potential of targeting mosquitoes of both sexes and females of varied physiological states; yet such lures are lacking for vectors of these diseases. Here, we present evidence of the effectiveness of linalool oxide (LO), a single plant-based lure previously developed for malaria vectors in trapping RVF vectors, Aedes mcintoshi and Aedes ochraceus, and dengue vector, Aedes aegypti. METHODS: For RVF vectors, we used CDC traps to evaluate the performance of LO against three vertebrate-based lures: CO(2) (dry ice), BioGent (BG) lure, and HONAD (a blend of aldehydes) in 2 experiments with Completely Randomized design: 1) using unlit CDC traps baited separately with LO, HONAD and BG-lure, and unlit CDC trap + CO(2) and lit CDC trap as controls, 2) similar treatments but with inclusion of CO(2) to all the traps. For dengue vectors, LO was evaluated against BG lure using BG sentinel traps, in a 3 × 6 Latin Square design, first as single lures and then combined with CO(2) and traps baited with CO(2) included as controls. Trap captures were compared between the treatments using Chi square and GLM. RESULTS: Low captures of RVF vectors were recorded for all lures in the absence of CO(2) with no significant difference between them. When combined with CO(2), LO performance in trapping these vectors was comparable to BG-lure and HONAD but it was less effective than the lit CDC trap. In the absence of CO(2), LO performed comparably with the BG-lure in trapping female Ae. aegypti, but with significantly higher males recorded in traps baited with the plant-based lure. When CO(2) was added, LO was significantly better than the BG-lure with a 2.8- fold increase in captures of male Ae. aegypti. CONCLUSIONS: These results highlight the potential of LO as a generalist plant-based lure for mosquito disease vectors, pending further assessment of possible specificity in their response profile to the different stereoisomers of this compound. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13071-015-1184-8) contains supplementary material, which is available to authorized users. BioMed Central 2015-11-09 /pmc/articles/PMC4640417/ /pubmed/26552398 http://dx.doi.org/10.1186/s13071-015-1184-8 Text en © Nyasembe et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Nyasembe, Vincent O.
Tchouassi, David P.
Mbogo, Charles M.
Sole, Catherine L.
Pirk, Christian
Torto, Baldwyn
Linalool oxide: generalist plant based lure for mosquito disease vectors
title Linalool oxide: generalist plant based lure for mosquito disease vectors
title_full Linalool oxide: generalist plant based lure for mosquito disease vectors
title_fullStr Linalool oxide: generalist plant based lure for mosquito disease vectors
title_full_unstemmed Linalool oxide: generalist plant based lure for mosquito disease vectors
title_short Linalool oxide: generalist plant based lure for mosquito disease vectors
title_sort linalool oxide: generalist plant based lure for mosquito disease vectors
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640417/
https://www.ncbi.nlm.nih.gov/pubmed/26552398
http://dx.doi.org/10.1186/s13071-015-1184-8
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