Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients

AIM: The present study aimed to evaluate the effects of gene variants in key genes influencing pharmacokinetic and pharmacodynamic of carbamazepine (CBZ) on the response in patients with epilepsy. MATERIALS & METHODS: Five SNPs in two candidate genes influencing CBZ transport and metabolism, nam...

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Detalles Bibliográficos
Autores principales: Daci, Armond, Beretta, Giangiacomo, Vllasaliu, Driton, Shala, Aida, Govori, Valbona, Norata, Giuseppe Danilo, Krasniqi, Shaip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640545/
https://www.ncbi.nlm.nih.gov/pubmed/26555147
http://dx.doi.org/10.1371/journal.pone.0142408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640545/
https://www.ncbi.nlm.nih.gov/pubmed/26555147
http://dx.doi.org/10.1371/journal.pone.0142408

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