Abacavir, an anti–HIV-1 drug, targets TDP1-deficient adult T cell leukemia

Adult T cell leukemia (ATL) is an aggressive T cell malignancy caused by human T cell leukemia virus type 1 (HTLV-1) and has a poor prognosis. We analyzed the cytotoxic effects of various nucleoside analog reverse transcriptase inhibitors (NRTIs) for HIV-1 on ATL cells and found that abacavir potent...

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Detalles Bibliográficos
Autores principales: Tada, Kohei, Kobayashi, Masayuki, Takiuchi, Yoko, Iwai, Fumie, Sakamoto, Takashi, Nagata, Kayoko, Shinohara, Masanobu, Io, Katsuhiro, Shirakawa, Kotaro, Hishizawa, Masakatsu, Shindo, Keisuke, Kadowaki, Norimitsu, Hirota, Kouji, Yamamoto, Junpei, Iwai, Shigenori, Sasanuma, Hiroyuki, Takeda, Shunichi, Takaori-Kondo, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640626/
https://www.ncbi.nlm.nih.gov/pubmed/26601161
http://dx.doi.org/10.1126/sciadv.1400203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640626/
https://www.ncbi.nlm.nih.gov/pubmed/26601161
http://dx.doi.org/10.1126/sciadv.1400203

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