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Functional Characterization of Cnidarian HCN Channels Points to an Early Evolution of I(h)

HCN channels play a unique role in bilaterian physiology as the only hyperpolarization-gated cation channels. Their voltage-gating is regulated by cyclic nucleotides and phosphatidylinositol 4,5-bisphosphate (PIP(2)). Activation of HCN channels provides the depolarizing current in response to hyperp...

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Detalles Bibliográficos
Autores principales:	Baker, Emma C., Layden, Michael J., van Rossum, Damian B., Kamel, Bishoy, Medina, Monica, Simpson, Eboni, Jegla, Timothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640657/ https://www.ncbi.nlm.nih.gov/pubmed/26555239 http://dx.doi.org/10.1371/journal.pone.0142730

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