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PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine
Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensiv...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640719/ https://www.ncbi.nlm.nih.gov/pubmed/26555441 http://dx.doi.org/10.1371/journal.pone.0142624 |
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author | Lee, Ji-Hyun Park, Kyoung Mii Han, Dong-Jin Bang, Nam Young Kim, Do-Hee Na, Hyeongjin Lim, Semi Kim, Tae Bum Kim, Dae Gyu Kim, Hyun-Jung Chung, Yeonseok Sung, Sang Hyun Surh, Young-Joon Kim, Sunghoon Han, Byung Woo |
author_facet | Lee, Ji-Hyun Park, Kyoung Mii Han, Dong-Jin Bang, Nam Young Kim, Do-Hee Na, Hyeongjin Lim, Semi Kim, Tae Bum Kim, Dae Gyu Kim, Hyun-Jung Chung, Yeonseok Sung, Sang Hyun Surh, Young-Joon Kim, Sunghoon Han, Byung Woo |
author_sort | Lee, Ji-Hyun |
collection | PubMed |
description | Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org. |
format | Online Article Text |
id | pubmed-4640719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46407192015-11-13 PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine Lee, Ji-Hyun Park, Kyoung Mii Han, Dong-Jin Bang, Nam Young Kim, Do-Hee Na, Hyeongjin Lim, Semi Kim, Tae Bum Kim, Dae Gyu Kim, Hyun-Jung Chung, Yeonseok Sung, Sang Hyun Surh, Young-Joon Kim, Sunghoon Han, Byung Woo PLoS One Research Article Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org. Public Library of Science 2015-11-10 /pmc/articles/PMC4640719/ /pubmed/26555441 http://dx.doi.org/10.1371/journal.pone.0142624 Text en © 2015 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Lee, Ji-Hyun Park, Kyoung Mii Han, Dong-Jin Bang, Nam Young Kim, Do-Hee Na, Hyeongjin Lim, Semi Kim, Tae Bum Kim, Dae Gyu Kim, Hyun-Jung Chung, Yeonseok Sung, Sang Hyun Surh, Young-Joon Kim, Sunghoon Han, Byung Woo PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine |
title | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine |
title_full | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine |
title_fullStr | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine |
title_full_unstemmed | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine |
title_short | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine |
title_sort | pharmdb-k: integrated bio-pharmacological network database for traditional korean medicine |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640719/ https://www.ncbi.nlm.nih.gov/pubmed/26555441 http://dx.doi.org/10.1371/journal.pone.0142624 |
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