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Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations

Lung cancer and chronic obstructive pulmonary disease (COPD) are two major lung diseases. Epidermal growth factor receptor (EGFR) mutations, v‐Ki‐ras2 Kirsten rat sarcoma (KRAS) mutations and anaplastic lymphoma kinase (ALK) gene rearrangements represent driver mutations that are frequently assessed...

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Autores principales: Lim, Jeong Uk, Yeo, Chang Dong, Rhee, Chin Kook, Kim, Yong Hyun, Park, Chan Kwon, Kim, Ju Sang, Kim, Jin Woo, Lee, Sang Haak, Kim, Seung Joon, Yoon, Hyoung Kyu, Kim, Tae-Jung, Lee, Kyo Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640806/
https://www.ncbi.nlm.nih.gov/pubmed/26555338
http://dx.doi.org/10.1371/journal.pone.0142306
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author Lim, Jeong Uk
Yeo, Chang Dong
Rhee, Chin Kook
Kim, Yong Hyun
Park, Chan Kwon
Kim, Ju Sang
Kim, Jin Woo
Lee, Sang Haak
Kim, Seung Joon
Yoon, Hyoung Kyu
Kim, Tae-Jung
Lee, Kyo Young
author_facet Lim, Jeong Uk
Yeo, Chang Dong
Rhee, Chin Kook
Kim, Yong Hyun
Park, Chan Kwon
Kim, Ju Sang
Kim, Jin Woo
Lee, Sang Haak
Kim, Seung Joon
Yoon, Hyoung Kyu
Kim, Tae-Jung
Lee, Kyo Young
author_sort Lim, Jeong Uk
collection PubMed
description Lung cancer and chronic obstructive pulmonary disease (COPD) are two major lung diseases. Epidermal growth factor receptor (EGFR) mutations, v‐Ki‐ras2 Kirsten rat sarcoma (KRAS) mutations and anaplastic lymphoma kinase (ALK) gene rearrangements represent driver mutations that are frequently assessed on initial evaluation of non-small-cell lung cancer (NSCLC). The present study focused on the expression of driver mutations in NSCLC patients presenting with COPD and further evaluated the association between NSCLC and COPD. Data from 501 consecutive patients with histologically proven recurrent or metastatic NSCLC were analyzed retrospectively. The patients underwent spirometry and genotyping of EGFR, ALK, and KRAS in tissue samples. Patient characteristics and expression of driver mutations were compared between the COPD and non-COPD groups. Among 350 patients with spirometric results, 106 (30.3%) were diagnosed with COPD, 108 (30.9%) had EGFR mutations, 31 (8.9%) had KRAS mutations, and 34 (9.7%) showed ALK rearrangements. COPD was independently associated with lower prevalences of EGFR mutations (95% confidence interval [CI], 0.254–0.931, p = 0.029) and ALK rearrangements (95% CI, 0.065–0.600, p = 0.004). The proportions of EGFR mutations and ALK rearrangements decreased as the severity of airflow obstruction increased (p = 0.001). In never smokers, the prevalence of EGFR mutations was significantly lower in the COPD group than in the non-COPD group (12.7% vs. 49.0%, p = 0.002). COPD-related NSCLC patients exhibited low prevalences of EGFR mutations and ALK rearrangements compared with the non-COPD group. Further studies are required regarding the molecular mechanisms underlying lung cancer associated with COPD.
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spelling pubmed-46408062015-11-13 Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations Lim, Jeong Uk Yeo, Chang Dong Rhee, Chin Kook Kim, Yong Hyun Park, Chan Kwon Kim, Ju Sang Kim, Jin Woo Lee, Sang Haak Kim, Seung Joon Yoon, Hyoung Kyu Kim, Tae-Jung Lee, Kyo Young PLoS One Research Article Lung cancer and chronic obstructive pulmonary disease (COPD) are two major lung diseases. Epidermal growth factor receptor (EGFR) mutations, v‐Ki‐ras2 Kirsten rat sarcoma (KRAS) mutations and anaplastic lymphoma kinase (ALK) gene rearrangements represent driver mutations that are frequently assessed on initial evaluation of non-small-cell lung cancer (NSCLC). The present study focused on the expression of driver mutations in NSCLC patients presenting with COPD and further evaluated the association between NSCLC and COPD. Data from 501 consecutive patients with histologically proven recurrent or metastatic NSCLC were analyzed retrospectively. The patients underwent spirometry and genotyping of EGFR, ALK, and KRAS in tissue samples. Patient characteristics and expression of driver mutations were compared between the COPD and non-COPD groups. Among 350 patients with spirometric results, 106 (30.3%) were diagnosed with COPD, 108 (30.9%) had EGFR mutations, 31 (8.9%) had KRAS mutations, and 34 (9.7%) showed ALK rearrangements. COPD was independently associated with lower prevalences of EGFR mutations (95% confidence interval [CI], 0.254–0.931, p = 0.029) and ALK rearrangements (95% CI, 0.065–0.600, p = 0.004). The proportions of EGFR mutations and ALK rearrangements decreased as the severity of airflow obstruction increased (p = 0.001). In never smokers, the prevalence of EGFR mutations was significantly lower in the COPD group than in the non-COPD group (12.7% vs. 49.0%, p = 0.002). COPD-related NSCLC patients exhibited low prevalences of EGFR mutations and ALK rearrangements compared with the non-COPD group. Further studies are required regarding the molecular mechanisms underlying lung cancer associated with COPD. Public Library of Science 2015-11-10 /pmc/articles/PMC4640806/ /pubmed/26555338 http://dx.doi.org/10.1371/journal.pone.0142306 Text en © 2015 Lim et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lim, Jeong Uk
Yeo, Chang Dong
Rhee, Chin Kook
Kim, Yong Hyun
Park, Chan Kwon
Kim, Ju Sang
Kim, Jin Woo
Lee, Sang Haak
Kim, Seung Joon
Yoon, Hyoung Kyu
Kim, Tae-Jung
Lee, Kyo Young
Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations
title Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations
title_full Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations
title_fullStr Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations
title_full_unstemmed Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations
title_short Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations
title_sort chronic obstructive pulmonary disease-related non-small-cell lung cancer exhibits a low prevalence of egfr and alk driver mutations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640806/
https://www.ncbi.nlm.nih.gov/pubmed/26555338
http://dx.doi.org/10.1371/journal.pone.0142306
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