Cargando…

Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma

BACKGROUND: Nucleolar and spindle-associated protein 1 (NUSAP1) is an important mitotic regulator. In addition to its crucial function in mitosis, NUSAP1 has recently received attention due to the interesting roles in carcinogenesis. The aim of this study was to reveal functional mechanisms of NUSAP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Okamoto, Atsushi, Higo, Morihiro, Shiiba, Masashi, Nakashima, Dai, Koyama, Tomoyoshi, Miyamoto, Isao, Kasama, Hiroki, Kasamatsu, Atsushi, Ogawara, Katsunori, Yokoe, Hidetaka, Tanzawa, Hideki, Uzawa, Katsuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640814/ https://www.ncbi.nlm.nih.gov/pubmed/26554377 http://dx.doi.org/10.1371/journal.pone.0142252

Ejemplares similares

WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice
por: Fukumoto, Chonji, et al.
Publicado: (2014)

ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer
por: Koyama, Tomoyoshi, et al.
Publicado: (2015)

Adenosine A2b receptor promotes progression of human oral cancer
por: Kasama, Hiroki, et al.
Publicado: (2015)

Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation
por: Kimura, Ryota, et al.
Publicado: (2013)

Treatment of an Extensive Maxillary Cyst Using Nasal Airway and Balloon Catheter Devices
por: Kasamatsu, Atsushi, et al.
Publicado: (2014)

Kinesin Family member 4A: A Potential Predictor for Progression of Human Oral Cancer
por: Minakawa, Yasuyuki, et al.
Publicado: (2013)

Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth
por: Miyamoto, Isao, et al.
Publicado: (2015)

Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer
por: Fukushima, Reo, et al.
Publicado: (2018)

Overexpression of LIM and SH3 Protein 1 Leading to Accelerated G2/M Phase Transition Contributes to Enhanced Tumourigenesis in Oral Cancer
por: Shimizu, Fumie, et al.
Publicado: (2013)

Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis
por: Saito, Tomoaki, et al.
Publicado: (2015)

Lysophosphatidylcholine Acyltransferase1 Overexpression Promotes Oral Squamous Cell Carcinoma Progression via Enhanced Biosynthesis of Platelet-Activating Factor
por: Shida-Sakazume, Tomomi, et al.
Publicado: (2015)

ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma
por: Kimura, Yasushi, et al.
Publicado: (2016)

Circulating tumor-derived mutant mitochondrial DNA: a predictive biomarker of clinical prognosis in human squamous cell carcinoma
por: Uzawa, Katsuhiro, et al.
Publicado: (2012)

Epithelial Cell Transforming Sequence 2 in Human Oral Cancer
por: Iyoda, Manabu, et al.
Publicado: (2010)

Annexin A10 in Human Oral Cancer: Biomarker for Tumoral Growth via G1/S Transition by Targeting MAPK Signaling Pathways
por: Shimizu, Toshihiro, et al.
Publicado: (2012)

Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest
por: Uchida, Fumihiko, et al.
Publicado: (2012)

Overexpression of CDCA2 in Human Squamous Cell Carcinoma: Correlation with Prevention of G1 Phase Arrest and Apoptosis
por: Uchida, Fumihiko, et al.
Publicado: (2013)

Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas
por: Kitajima, Daisuke, et al.
Publicado: (2016)

Targeting phosphodiesterase 3B enhances cisplatin sensitivity in human cancer cells
por: Uzawa, Katsuhiro, et al.
Publicado: (2013)

Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells
por: Uzawa, Katsuhiro, et al.
Publicado: (2014)

Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis
por: Komatsu, Mari, et al.
Publicado: (2022)

Nucleolar spindle associated protein 1 (NUSAP1) facilitates proliferation of hepatocellular carcinoma cells
por: Hou, Sinan, et al.
Publicado: (2019)

Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma
por: Hamana, K, et al.
Publicado: (2005)

Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis
por: Kouzu, Y, et al.
Publicado: (2006)

Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis
por: Kita, Akihiro, et al.
Publicado: (2017)

Maxillary Swelling as the First Evidence of Multiple Myeloma
por: Kasamatsu, Atsushi, et al.
Publicado: (2015)

Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: an immunohistochemical study of premalignant and malignant lesions of the oral cavity
por: Nomura, Hitomi, et al.
Publicado: (2008)

SYT12 plays a critical role in oral cancer and may be a novel therapeutic target
por: Eizuka, Keitaro, et al.
Publicado: (2019)

Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer
por: Koide, Nao, et al.
Publicado: (2017)

MicroRNAs in Head and Neck Squamous Cell Carcinoma (HNSCC) and Oral Squamous Cell Carcinoma (OSCC)
por: Shiiba, Masashi, et al.
Publicado: (2010)

Nucleolar and Spindle Associated Protein 1 (NUSAP1) Promotes Bladder Cancer Progression Through the TGF-β Signaling Pathway
por: Gao, Shun, et al.
Publicado: (2020)

Distinct Mitotic Functions of Nucleolar and Spindle-Associated Protein 1 (NuSAP1) Are Controlled by Two Consensus SUMOylation Sites
por: Damizia, Michela, et al.
Publicado: (2023)

A novel cell-based transplantation method using a Rho kinase inhibitor and a specific catheter device for the treatment of salivary gland damage after head and neck radiotherapy
por: Kasamatsu, Atsushi, et al.
Publicado: (2022)

Network-based analysis of calcium-binding protein genes identifies Grp94 as a target in human oral carcinogenesis
por: Nomura, H, et al.
Publicado: (2007)

Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma
por: Minemura, Chikashi, et al.
Publicado: (2022)

MicroRNA-125b regulates proliferation and radioresistance of oral squamous cell carcinoma
por: Shiiba, M, et al.
Publicado: (2013)

Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma
por: Uzawa, Katsuhiro, et al.
Publicado: (2019)

Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression
por: Kase, Yutaro, et al.
Publicado: (2021)

Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement
por: Oka, Noritoshi, et al.
Publicado: (2019)

Tumor Suppressive Circular RNA-102450: Development of a Novel Diagnostic Procedure for Lymph Node Metastasis from Oral Cancer
por: Ando, Toshiaki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qtomvsc0k6v75e33n3hqlif8ne