Heme-Mediated Induction of CXCL10 and Depletion of CD34+ Progenitor Cells Is Toll-Like Receptor 4 Dependent

Plasmodium falciparum infection can cause microvascular dysfunction, cerebral encephalopathy and death if untreated. We have previously shown that high concentrations of free heme, and C-X-C motif chemokine 10 (CXCL10) in sera of malaria patients induce apoptosis in microvascular endothelial and neu...

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Detalles Bibliográficos
Autores principales: Dickinson-Copeland, Carmen M., Wilson, Nana O., Liu, Mingli, Driss, Adel, Salifu, Hassana, Adjei, Andrew A., Wilson, Michael, Gyan, Ben, Oduro, Daniel, Badu, Kingsley, Botchway, Felix, Anderson, Winston, Bond, Vincent, Bacanamwo, Methode, Singh, Shailesh, Stiles, Jonathan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640861/
https://www.ncbi.nlm.nih.gov/pubmed/26555697
http://dx.doi.org/10.1371/journal.pone.0142328

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