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Evaluation of a Novel Tc-99m Labelled Vitamin B(12) Derivative for Targeting Escherichia coli and Staphylococcus aureus In Vitro and in an Experimental Foreign-Body Infection Model
PURPOSE: Vitamin B(12) (cyanocobalamin, Cbl) is accumulated by rapidly replicating prokaryotic and eukaryotic cells. We investigated the potential of a Tc-99m labelled Cbl derivative ([(99m)Tc]PAMA(4)-Cbl) for targeting infections caused by Escherichia coli and Staphylococcus aureus. In vitro bindin...
Autores principales: | Baldoni, Daniela, Waibel, Robert, Bläuenstein, Peter, Galli, Filippo, Iodice, Violetta, Signore, Alberto, Schibli, Roger, Trampuz, Andrej |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641156/ https://www.ncbi.nlm.nih.gov/pubmed/25860122 http://dx.doi.org/10.1007/s11307-015-0832-x |
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