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Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population

BACKGROUND & OBJECTIVES: Attention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this diso...

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Autores principales: Kayyal, Matin, Movafagh, Abolfazl, Hashemi, Mehrdad, Sayad, Arezou, Emamalizadeh, Babak, PourIran, Khashayar, Kayyal, Mohammadmoien, Amirabadi, Mohammad Reza Eslami, Zamani, Mahdi, Darvish, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641275/
https://www.ncbi.nlm.nih.gov/pubmed/26649006
http://dx.doi.org/10.12669/pjms.315.8132
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author Kayyal, Matin
Movafagh, Abolfazl
Hashemi, Mehrdad
Sayad, Arezou
Emamalizadeh, Babak
PourIran, Khashayar
Kayyal, Mohammadmoien
Amirabadi, Mohammad Reza Eslami
Zamani, Mahdi
Darvish, Hossein
author_facet Kayyal, Matin
Movafagh, Abolfazl
Hashemi, Mehrdad
Sayad, Arezou
Emamalizadeh, Babak
PourIran, Khashayar
Kayyal, Mohammadmoien
Amirabadi, Mohammad Reza Eslami
Zamani, Mahdi
Darvish, Hossein
author_sort Kayyal, Matin
collection PubMed
description BACKGROUND & OBJECTIVES: Attention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs rs11122319, rs11122330 and rs6675281 in the etiology of ADHD in an Iranian children METHODS: In this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISC1 gene with ADHD in Iranian population. Two hundred fourthy subjects composed of 120 patients and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs. RESULTS: We found differences in genotype and allele distributions of rs 6675281 polymorphism between our patients and controls. The A, T and A alleles were the more frequent alleles in rs11122319, rs6675281 and rs11122330 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to patients. (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776). CONCLUSION: Our findings strengthens the role of DISC1 gene as a susceptibility locus for ADHD and indicate that rs6675281 polymorphism is a susceptibility factor for ADHD for the first time in children reported in an Iranian population in this part of the world.
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spelling pubmed-46412752015-12-08 Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population Kayyal, Matin Movafagh, Abolfazl Hashemi, Mehrdad Sayad, Arezou Emamalizadeh, Babak PourIran, Khashayar Kayyal, Mohammadmoien Amirabadi, Mohammad Reza Eslami Zamani, Mahdi Darvish, Hossein Pak J Med Sci Original Article BACKGROUND & OBJECTIVES: Attention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs rs11122319, rs11122330 and rs6675281 in the etiology of ADHD in an Iranian children METHODS: In this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISC1 gene with ADHD in Iranian population. Two hundred fourthy subjects composed of 120 patients and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs. RESULTS: We found differences in genotype and allele distributions of rs 6675281 polymorphism between our patients and controls. The A, T and A alleles were the more frequent alleles in rs11122319, rs6675281 and rs11122330 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to patients. (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776). CONCLUSION: Our findings strengthens the role of DISC1 gene as a susceptibility locus for ADHD and indicate that rs6675281 polymorphism is a susceptibility factor for ADHD for the first time in children reported in an Iranian population in this part of the world. Professional Medical Publications 2015 /pmc/articles/PMC4641275/ /pubmed/26649006 http://dx.doi.org/10.12669/pjms.315.8132 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kayyal, Matin
Movafagh, Abolfazl
Hashemi, Mehrdad
Sayad, Arezou
Emamalizadeh, Babak
PourIran, Khashayar
Kayyal, Mohammadmoien
Amirabadi, Mohammad Reza Eslami
Zamani, Mahdi
Darvish, Hossein
Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population
title Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population
title_full Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population
title_fullStr Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population
title_full_unstemmed Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population
title_short Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population
title_sort association analysis of disc1 gene polymorphisms with attention-deficit hyperactivity disorder in iranian population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641275/
https://www.ncbi.nlm.nih.gov/pubmed/26649006
http://dx.doi.org/10.12669/pjms.315.8132
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