Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia

Decreased autophagy contributes to malignancies; however, it is unclear how autophagy has an impact on tumor growth. Acute myeloid leukemia (AML) is an ideal model to address this as (i) patient samples are easily accessible, (ii) the hematopoietic stem and progenitor cells (HSPC) where transformati...

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Detalles Bibliográficos
Autores principales: Watson, AS, Riffelmacher, T, Stranks, A, Williams, O, De Boer, J, Cain, K, MacFarlane, M, McGouran, J, Kessler, B, Khandwala, S, Chowdhury, O, Puleston, D, Phadwal, K, Mortensen, M, Ferguson, D, Soilleux, E, Woll, P, Jacobsen, SEW, Simon, AK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641322/
https://www.ncbi.nlm.nih.gov/pubmed/26568842
http://dx.doi.org/10.1038/cddiscovery.2015.8

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