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Dynamic Co-evolution of Host and Pathogen: HCMV Downregulates the Prevalent Allele MICA*008 to Escape Elimination by NK Cells
Natural killer (NK) cells mediate innate immune responses against hazardous cells and are particularly important for the control of human cytomegalovirus (HCMV). NKG2D is a key NK activating receptor that recognizes a family of stress-induced ligands, including MICA, MICB, and ULBP1-6. Notably, most...
Autores principales: | Seidel, Einat, Le, Vu Thuy Khanh, Bar-On, Yotam, Tsukerman, Pinchas, Enk, Jonatan, Yamin, Rachel, Stein, Natan, Schmiedel, Dominik, Djian, Esther Oiknine, Weisblum, Yiska, Tirosh, Boaz, Stastny, Peter, Wolf, Dana G., Hengel, Hartmut, Mandelboim, Ofer |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641326/ https://www.ncbi.nlm.nih.gov/pubmed/25683719 http://dx.doi.org/10.1016/j.celrep.2015.01.029 |
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