Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

INTRODUCTION: Amyloid β (Aβ) accumulates in the extracellular space as diffuse and neuritic plaques in Alzheimer’s disease (AD). Aβ also deposits on the walls of arterioles as cerebral amyloid angiopathy (CAA) in most cases of AD and sometimes independently of AD. Apolipoprotein E (apoE) ɛ4 is assoc...

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Detalles Bibliográficos
Autores principales: Liao, Fan, Zhang, Tony J., Jiang, Hong, Lefton, Katheryn B., Robinson, Grace O., Vassar, Robert, Sullivan, Patrick M., Holtzman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641345/
https://www.ncbi.nlm.nih.gov/pubmed/26556230
http://dx.doi.org/10.1186/s40478-015-0250-y

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