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Guidelines for treatment of immune-mediated cerebellar ataxias

Immune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto’s encephalopathy. Despite the identification of an increasing number of immune-mediated cerebellar ataxias, there is no proposed standardized the...

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Detalles Bibliográficos
Autores principales: Mitoma, Hiroshi, Hadjivassiliou, Marios, Honnorat, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641375/
https://www.ncbi.nlm.nih.gov/pubmed/26561527
http://dx.doi.org/10.1186/s40673-015-0034-y
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author Mitoma, Hiroshi
Hadjivassiliou, Marios
Honnorat, Jérôme
author_facet Mitoma, Hiroshi
Hadjivassiliou, Marios
Honnorat, Jérôme
author_sort Mitoma, Hiroshi
collection PubMed
description Immune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto’s encephalopathy. Despite the identification of an increasing number of immune-mediated cerebellar ataxias, there is no proposed standardized therapy. We evaluated the efficacies of immunotherapies in reported cases using a common scale of daily activity. The analysis highlighted the importance of removal of autoimmune triggering factors (e.g., gluten or cancer) and the need for immunotherapy evaluation (e.g., corticosteroids, intravenous immunoglobulin, immunosuppressants) and adaptation according to each subtype. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40673-015-0034-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-46413752015-11-12 Guidelines for treatment of immune-mediated cerebellar ataxias Mitoma, Hiroshi Hadjivassiliou, Marios Honnorat, Jérôme Cerebellum Ataxias Review Immune-mediated cerebellar ataxias include gluten ataxia, paraneoplastic cerebellar degeneration, GAD antibody associated cerebellar ataxia, and Hashimoto’s encephalopathy. Despite the identification of an increasing number of immune-mediated cerebellar ataxias, there is no proposed standardized therapy. We evaluated the efficacies of immunotherapies in reported cases using a common scale of daily activity. The analysis highlighted the importance of removal of autoimmune triggering factors (e.g., gluten or cancer) and the need for immunotherapy evaluation (e.g., corticosteroids, intravenous immunoglobulin, immunosuppressants) and adaptation according to each subtype. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40673-015-0034-y) contains supplementary material, which is available to authorized users. BioMed Central 2015-11-10 /pmc/articles/PMC4641375/ /pubmed/26561527 http://dx.doi.org/10.1186/s40673-015-0034-y Text en © Mitoma et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mitoma, Hiroshi
Hadjivassiliou, Marios
Honnorat, Jérôme
Guidelines for treatment of immune-mediated cerebellar ataxias
title Guidelines for treatment of immune-mediated cerebellar ataxias
title_full Guidelines for treatment of immune-mediated cerebellar ataxias
title_fullStr Guidelines for treatment of immune-mediated cerebellar ataxias
title_full_unstemmed Guidelines for treatment of immune-mediated cerebellar ataxias
title_short Guidelines for treatment of immune-mediated cerebellar ataxias
title_sort guidelines for treatment of immune-mediated cerebellar ataxias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641375/
https://www.ncbi.nlm.nih.gov/pubmed/26561527
http://dx.doi.org/10.1186/s40673-015-0034-y
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