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An N-Acetyl Cysteine Ruthenium Tricarbonyl Conjugate Enables Simultaneous Release of CO and Ablation of Reactive Oxygen Species

We have designed and synthesised a [Ru(CO)(3)Cl(2)(NAC)] pro-drug that features an N-acetyl cysteine (NAC) ligand. This NAC carbon monoxide releasing molecule (CORM) conjugate is able to simultaneously release biologically active CO and to ablate the concurrent formation of reactive oxygen species (...

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Detalles Bibliográficos
Autores principales:	Seixas, João D, Chaves-Ferreira, Miguel, Montes-Grajales, Diana, Gonçalves, Ana M, Marques, Ana R, Saraiva, Lígia M, Olivero-Verbel, Jesus, Romão, Carlos C, Bernardes, Gonçalo J L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641457/ https://www.ncbi.nlm.nih.gov/pubmed/26316066 http://dx.doi.org/10.1002/chem.201502474

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