Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity

Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement-mediated hemolysis in a patient whose hemodynamic status...

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Detalles Bibliográficos
Autores principales: Shapiro, Roman, Chin-Yee, Ian, Lam, Selay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641479/
https://www.ncbi.nlm.nih.gov/pubmed/26576277
http://dx.doi.org/10.1002/ccr3.399
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author Shapiro, Roman
Chin-Yee, Ian
Lam, Selay
author_facet Shapiro, Roman
Chin-Yee, Ian
Lam, Selay
author_sort Shapiro, Roman
collection PubMed
description Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement-mediated hemolysis in a patient whose hemodynamic status deteriorated in spite of supportive blood transfusions and therapeutic plasma exchange.
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spelling pubmed-46414792015-11-16 Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity Shapiro, Roman Chin-Yee, Ian Lam, Selay Clin Case Rep Case Reports Severe cold agglutinin disease with hemodynamic compromise requires rapid stabilization of the autoimmune hemolytic anemia as a bridge to the immunosuppressive effect of rituximab. Herein, we describe eculizumab treatment of severe complement-mediated hemolysis in a patient whose hemodynamic status deteriorated in spite of supportive blood transfusions and therapeutic plasma exchange. John Wiley & Sons, Ltd 2015-11 2015-09-29 /pmc/articles/PMC4641479/ /pubmed/26576277 http://dx.doi.org/10.1002/ccr3.399 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Case Reports
Shapiro, Roman
Chin-Yee, Ian
Lam, Selay
Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity
title Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity
title_full Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity
title_fullStr Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity
title_full_unstemmed Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity
title_short Eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-Pr specificity
title_sort eculizumab as a bridge to immunosuppressive therapy in severe cold agglutinin disease of anti-pr specificity
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641479/
https://www.ncbi.nlm.nih.gov/pubmed/26576277
http://dx.doi.org/10.1002/ccr3.399
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