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A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x(c)(−) Mediates Aglycemic Neuronal Cell Death

The astrocyte cystine/glutamate antiporter (system x(c)(−)) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred. Using pure astrocyte cultures, as well as, mixed cortical...

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Detalles Bibliográficos
Autores principales:	Thorn, Trista L., He, Yan, Jackman, Nicole A., Lobner, Doug, Hewett, James A., Hewett, Sandra J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641554/ https://www.ncbi.nlm.nih.gov/pubmed/26553727 http://dx.doi.org/10.1177/1759091415614301

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