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Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation

Endothelial nitric oxide synthase (eNOS) is responsible for maintaining systemic blood pressure, vascular remodeling and angiogenesis. In addition to producing NO, eNOS can also generate superoxide (O(2) (-.)) in the absence of the cofactor tetrahydrobiopterin (BH4). Previous studies have shown that...

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Detalles Bibliográficos
Autores principales:	Peng, Hu, Zhuang, Yugang, Harbeck, Mark C., He, Donghong, Xie, Lishi, Chen, Weiguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641627/ https://www.ncbi.nlm.nih.gov/pubmed/26560496 http://dx.doi.org/10.1371/journal.pone.0142854

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