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Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases

BACKGROUND: In patients with pulmonary tuberculosis (TB), shortening the time to sputum culture conversion is desirable to reduce the likelihood of mycobacterial transmission. A persistent positive sputum culture after 2 months of treatment is reported to be associated with the presence of cavitatio...

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Autores principales: Kanda, Rie, Nagao, Taishi, Tho, Nguyen Van, Ogawa, Emiko, Murakami, Yoshitaka, Osawa, Makoto, Saika, Yoshinori, Doi, Kenji, Nakano, Yasutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641703/
https://www.ncbi.nlm.nih.gov/pubmed/26558764
http://dx.doi.org/10.1371/journal.pone.0142607
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author Kanda, Rie
Nagao, Taishi
Tho, Nguyen Van
Ogawa, Emiko
Murakami, Yoshitaka
Osawa, Makoto
Saika, Yoshinori
Doi, Kenji
Nakano, Yasutaka
author_facet Kanda, Rie
Nagao, Taishi
Tho, Nguyen Van
Ogawa, Emiko
Murakami, Yoshitaka
Osawa, Makoto
Saika, Yoshinori
Doi, Kenji
Nakano, Yasutaka
author_sort Kanda, Rie
collection PubMed
description BACKGROUND: In patients with pulmonary tuberculosis (TB), shortening the time to sputum culture conversion is desirable to reduce the likelihood of mycobacterial transmission. A persistent positive sputum culture after 2 months of treatment is reported to be associated with the presence of cavitation and the extent of disease on chest X-ray, high colony count, diabetes mellitus, and smoking. However, little is known about factors affecting the time to sputum culture conversion. This study was conducted to evaluate factors affecting the time to sputum culture conversion throughout the course of treatment in adults with pulmonary TB. METHODS: This study was performed using a database of the medical records of patients with active pulmonary TB who were treated at Hirakata Kohsai Hospital in Hirakata City, Osaka, Japan, from October 2000 to October 2002. Cox proportional-hazards analysis was used to evaluate factors affecting the time to sputum culture conversion after adjusting for potential confounders. RESULTS: The data of 86 patients with pulmonary TB were analyzed. The median time to sputum culture conversion was 39 days, and the maximum time was 116 days. The Cox proportional-hazards analysis showed that a higher smear grading (HR, 0.40; 95%CI, 0.23–0.71) and a history of ever smoking (HR, 0.48; 95%CI, 0.25–0.94) were associated with delayed sputum culture conversion. CONCLUSION: High smear grading and smoking prolonged the time to sputum culture conversion in adults with pulmonary TB. To effectively control TB, measures to decrease the cigarette smoking rate should be implemented, in addition to early detection and timely anti-TB treatment.
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spelling pubmed-46417032015-11-18 Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases Kanda, Rie Nagao, Taishi Tho, Nguyen Van Ogawa, Emiko Murakami, Yoshitaka Osawa, Makoto Saika, Yoshinori Doi, Kenji Nakano, Yasutaka PLoS One Research Article BACKGROUND: In patients with pulmonary tuberculosis (TB), shortening the time to sputum culture conversion is desirable to reduce the likelihood of mycobacterial transmission. A persistent positive sputum culture after 2 months of treatment is reported to be associated with the presence of cavitation and the extent of disease on chest X-ray, high colony count, diabetes mellitus, and smoking. However, little is known about factors affecting the time to sputum culture conversion. This study was conducted to evaluate factors affecting the time to sputum culture conversion throughout the course of treatment in adults with pulmonary TB. METHODS: This study was performed using a database of the medical records of patients with active pulmonary TB who were treated at Hirakata Kohsai Hospital in Hirakata City, Osaka, Japan, from October 2000 to October 2002. Cox proportional-hazards analysis was used to evaluate factors affecting the time to sputum culture conversion after adjusting for potential confounders. RESULTS: The data of 86 patients with pulmonary TB were analyzed. The median time to sputum culture conversion was 39 days, and the maximum time was 116 days. The Cox proportional-hazards analysis showed that a higher smear grading (HR, 0.40; 95%CI, 0.23–0.71) and a history of ever smoking (HR, 0.48; 95%CI, 0.25–0.94) were associated with delayed sputum culture conversion. CONCLUSION: High smear grading and smoking prolonged the time to sputum culture conversion in adults with pulmonary TB. To effectively control TB, measures to decrease the cigarette smoking rate should be implemented, in addition to early detection and timely anti-TB treatment. Public Library of Science 2015-11-11 /pmc/articles/PMC4641703/ /pubmed/26558764 http://dx.doi.org/10.1371/journal.pone.0142607 Text en © 2015 Kanda et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kanda, Rie
Nagao, Taishi
Tho, Nguyen Van
Ogawa, Emiko
Murakami, Yoshitaka
Osawa, Makoto
Saika, Yoshinori
Doi, Kenji
Nakano, Yasutaka
Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases
title Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases
title_full Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases
title_fullStr Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases
title_full_unstemmed Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases
title_short Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases
title_sort factors affecting time to sputum culture conversion in adults with pulmonary tuberculosis: a historical cohort study without censored cases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641703/
https://www.ncbi.nlm.nih.gov/pubmed/26558764
http://dx.doi.org/10.1371/journal.pone.0142607
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