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Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome

Clustered DNA damage is defined as multiple sites of DNA damage within one or two helical turns of the duplex DNA. This complex damage is often formed by exposure of the genome to ionizing radiation and is difficult to repair. The mutagenic potential and repair mechanisms of clustered DNA damage in...

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Detalles Bibliográficos
Autores principales: Sassa, Akira, Kamoshita, Nagisa, Kanemaru, Yuki, Honma, Masamitsu, Yasui, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641734/
https://www.ncbi.nlm.nih.gov/pubmed/26559182
http://dx.doi.org/10.1371/journal.pone.0142218