Mutations in RNA Polymerase Bridge Helix and Switch Regions Affect Active-Site Networks and Transcript-Assisted Hydrolysis

In bacterial RNA polymerase (RNAP), the bridge helix and switch regions form an intricate network with the catalytic active centre and the main channel. These interactions are important for catalysis, hydrolysis and clamp domain movement. By targeting conserved residues in Escherichia coli RNAP, we...

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Detalles Bibliográficos
Autores principales: Zhang, Nan, Schäfer, Jorrit, Sharma, Amit, Rayner, Lucy, Zhang, Xiaodong, Tuma, Roman, Stockley, Peter, Buck, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641871/
https://www.ncbi.nlm.nih.gov/pubmed/26365052
http://dx.doi.org/10.1016/j.jmb.2015.09.005

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