A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method

An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by sp...

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Detalles Bibliográficos
Autores principales: Ambethkar, Sethurajan, Padmini, Vediappen, Bhuvanesh, Nattamai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642161/
https://www.ncbi.nlm.nih.gov/pubmed/26644936
http://dx.doi.org/10.1016/j.jare.2014.11.011
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author Ambethkar, Sethurajan
Padmini, Vediappen
Bhuvanesh, Nattamai
author_facet Ambethkar, Sethurajan
Padmini, Vediappen
Bhuvanesh, Nattamai
author_sort Ambethkar, Sethurajan
collection PubMed
description An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by spectroscopic techniques and the compounds were further evaluated for their in vitro antioxidant and antimicrobial activities.
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spelling pubmed-46421612015-12-07 A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method Ambethkar, Sethurajan Padmini, Vediappen Bhuvanesh, Nattamai J Adv Res Original Article An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by spectroscopic techniques and the compounds were further evaluated for their in vitro antioxidant and antimicrobial activities. Elsevier 2015-11 2014-11-25 /pmc/articles/PMC4642161/ /pubmed/26644936 http://dx.doi.org/10.1016/j.jare.2014.11.011 Text en © 2014 Production and hosting by Elsevier B.V. on behalf of Cairo University. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Original Article
Ambethkar, Sethurajan
Padmini, Vediappen
Bhuvanesh, Nattamai
A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_full A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_fullStr A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_full_unstemmed A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_short A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
title_sort green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642161/
https://www.ncbi.nlm.nih.gov/pubmed/26644936
http://dx.doi.org/10.1016/j.jare.2014.11.011
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