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Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling

Hyperactivated RAS drives progression of many human malignancies. However, oncogenic activity of RAS is dependent on simultaneous inactivation of protein phosphatase 2A (PP2A) activity. Although PP2A is known to regulate some of the RAS effector pathways, it has not been systematically assessed how...

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Detalles Bibliográficos
Autores principales:	Kauko, Otto, Laajala, Teemu Daniel, Jumppanen, Mikael, Hintsanen, Petteri, Suni, Veronika, Haapaniemi, Pekka, Corthals, Garry, Aittokallio, Tero, Westermarck, Jukka, Imanishi, Susumu Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642524/ https://www.ncbi.nlm.nih.gov/pubmed/26278961 http://dx.doi.org/10.1038/srep13099

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