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Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1

Investigating the in vivo role of tumor suppressor genes in cancer is technically challenging due to their essential requirement during early animal development. To address this bottleneck, we generated genetic mosaic adult zebrafish using TALEN genome editing and demonstrate somatic inactivation of...

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Detalles Bibliográficos
Autores principales:	Solin, Staci L., Shive, Heather R., Woolard, Kevin D., Essner, Jeffrey J., McGrail, Maura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642565/ https://www.ncbi.nlm.nih.gov/pubmed/26345384 http://dx.doi.org/10.1038/srep13745

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