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Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan
INTRODUCTION: The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older. METHODS: Data were r...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642684/ https://www.ncbi.nlm.nih.gov/pubmed/26560125 http://dx.doi.org/10.1186/s13195-015-0150-1 |
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author | Sun, Yi-Hua Nfor, Oswald Ndi Huang, Jing-Yang Liaw, Yung-Po |
author_facet | Sun, Yi-Hua Nfor, Oswald Ndi Huang, Jing-Yang Liaw, Yung-Po |
author_sort | Sun, Yi-Hua |
collection | PubMed |
description | INTRODUCTION: The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older. METHODS: Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer’s disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0. RESULTS: Individuals exposed to amalgam fillings had higher risk of Alzheimer’s disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer's disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women. CONCLUSIONS: Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer’s disease than were their non-exposed counterparts. |
format | Online Article Text |
id | pubmed-4642684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46426842015-11-13 Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan Sun, Yi-Hua Nfor, Oswald Ndi Huang, Jing-Yang Liaw, Yung-Po Alzheimers Res Ther Research INTRODUCTION: The potential effects of amalgam fillings on the development of Alzheimer’s disease (AD) are not well understood. The aim of the study was to evaluate the association between dental amalgam fillings and Alzheimer’s disease in Taiwanese population aged 65 and older. METHODS: Data were retrieved from the Longitudinal Health Insurance Database (LHID 2005 and 2010). The study enrolled 1,943,702 beneficiaries from the LHID database. After excluding death cases and individuals aged 65 and under, 207,587 enrollees were finally involved in the study. Dental amalgam fillings are coded as 89001C, 89002C, 89003C, 89101C, 89102C, or 89103C in the national health insurance research database (NHIRD). Alzheimer’s disease was diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 331.0. RESULTS: Individuals exposed to amalgam fillings had higher risk of Alzheimer’s disease (odds ratio, OR = 1.105, 95 % confidence interval, CI = 1.025-1.190) than their non-exposed counterparts. Further analysis showed that the odds ratio of Ahlzheimer's disease was 1.07 (95 % CI = 0.962-1.196) in men and 1.132 (95 % CI = 1.022-1.254) in women. CONCLUSIONS: Women who were exposed to amalgam fillings were 1.132 times more likely to have Alzheimer’s disease than were their non-exposed counterparts. BioMed Central 2015-11-12 /pmc/articles/PMC4642684/ /pubmed/26560125 http://dx.doi.org/10.1186/s13195-015-0150-1 Text en © Sun et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Sun, Yi-Hua Nfor, Oswald Ndi Huang, Jing-Yang Liaw, Yung-Po Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan |
title | Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan |
title_full | Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan |
title_fullStr | Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan |
title_full_unstemmed | Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan |
title_short | Association between dental amalgam fillings and Alzheimer’s disease: a population-based cross-sectional study in Taiwan |
title_sort | association between dental amalgam fillings and alzheimer’s disease: a population-based cross-sectional study in taiwan |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642684/ https://www.ncbi.nlm.nih.gov/pubmed/26560125 http://dx.doi.org/10.1186/s13195-015-0150-1 |
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