Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health

The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and female gametes. In the present review, we focused our attention to the role played by epigenet...

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Autores principales: Stuppia, Liborio, Franzago, Marica, Ballerini, Patrizia, Gatta, Valentina, Antonucci, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642754/
https://www.ncbi.nlm.nih.gov/pubmed/26566402
http://dx.doi.org/10.1186/s13148-015-0155-4
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author Stuppia, Liborio
Franzago, Marica
Ballerini, Patrizia
Gatta, Valentina
Antonucci, Ivana
author_facet Stuppia, Liborio
Franzago, Marica
Ballerini, Patrizia
Gatta, Valentina
Antonucci, Ivana
author_sort Stuppia, Liborio
collection PubMed
description The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and female gametes. In the present review, we focused our attention to the role played by epigenetics on male reproduction, evidencing at least four different levels at which sperm epigenetic modifications could affect reproduction: (1) spermatogenesis failure; (2) embryo development; (3) outcome of assisted reproduction technique (ART) protocols, mainly as concerning genomic imprinting; and (4) long-term effects during the offspring lifetime. The environmental agents responsible for epigenetic modifications are also examined, suggesting that the control of paternal lifestyle prior to conception could represent in the next future a novel hot topic in the management of human reproduction.
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spelling pubmed-46427542015-11-13 Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health Stuppia, Liborio Franzago, Marica Ballerini, Patrizia Gatta, Valentina Antonucci, Ivana Clin Epigenetics Review The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and female gametes. In the present review, we focused our attention to the role played by epigenetics on male reproduction, evidencing at least four different levels at which sperm epigenetic modifications could affect reproduction: (1) spermatogenesis failure; (2) embryo development; (3) outcome of assisted reproduction technique (ART) protocols, mainly as concerning genomic imprinting; and (4) long-term effects during the offspring lifetime. The environmental agents responsible for epigenetic modifications are also examined, suggesting that the control of paternal lifestyle prior to conception could represent in the next future a novel hot topic in the management of human reproduction. BioMed Central 2015-11-11 /pmc/articles/PMC4642754/ /pubmed/26566402 http://dx.doi.org/10.1186/s13148-015-0155-4 Text en © Stuppia et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Stuppia, Liborio
Franzago, Marica
Ballerini, Patrizia
Gatta, Valentina
Antonucci, Ivana
Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
title Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
title_full Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
title_fullStr Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
title_full_unstemmed Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
title_short Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
title_sort epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642754/
https://www.ncbi.nlm.nih.gov/pubmed/26566402
http://dx.doi.org/10.1186/s13148-015-0155-4
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