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Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice

BACKGROUND: Tumor progression locus 2 (TPL2), a serine-threonine kinase, functions as a critical regulator of inflammatory pathways and mediates oncogenic events. The potential role of Tpl2 in nonalcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) development remains unkn...

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Detalles Bibliográficos
Autores principales:	Li, Xinli, Liu, Chun, Ip, Blanche C., Hu, Kang-Quan, Smith, Donald E., Greenberg, Andrew S., Wang, Xiang-Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642781/ https://www.ncbi.nlm.nih.gov/pubmed/26560698 http://dx.doi.org/10.1186/s13046-015-0254-2

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