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Studying cell biology in the skin

Advances in cell biology have often been driven by studies in diverse organisms and cell types. Although there are technical reasons for why different cell types are used, there are also important physiological reasons. For example, ultrastructural studies of vesicle transport were aided by the use...

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Detalles Bibliográficos
Autores principales: Morrow, Angel, Lechler, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642852/
https://www.ncbi.nlm.nih.gov/pubmed/26564861
http://dx.doi.org/10.1091/mbc.E15-04-0246
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author Morrow, Angel
Lechler, Terry
author_facet Morrow, Angel
Lechler, Terry
author_sort Morrow, Angel
collection PubMed
description Advances in cell biology have often been driven by studies in diverse organisms and cell types. Although there are technical reasons for why different cell types are used, there are also important physiological reasons. For example, ultrastructural studies of vesicle transport were aided by the use of professional secretory cell types. The use of tissues/primary cells has the advantage not only of using cells that are adapted to the use of certain cell biological machinery, but also of highlighting the physiological roles of this machinery. Here we discuss advantages of the skin as a model system. We discuss both advances in cell biology that used the skin as a driving force and future prospects for use of the skin to understand basic cell biology. A unique combination of characteristics and tools makes the skin a useful in vivo model system for many cell biologists.
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spelling pubmed-46428522016-01-30 Studying cell biology in the skin Morrow, Angel Lechler, Terry Mol Biol Cell Perspective Advances in cell biology have often been driven by studies in diverse organisms and cell types. Although there are technical reasons for why different cell types are used, there are also important physiological reasons. For example, ultrastructural studies of vesicle transport were aided by the use of professional secretory cell types. The use of tissues/primary cells has the advantage not only of using cells that are adapted to the use of certain cell biological machinery, but also of highlighting the physiological roles of this machinery. Here we discuss advantages of the skin as a model system. We discuss both advances in cell biology that used the skin as a driving force and future prospects for use of the skin to understand basic cell biology. A unique combination of characteristics and tools makes the skin a useful in vivo model system for many cell biologists. The American Society for Cell Biology 2015-11-15 /pmc/articles/PMC4642852/ /pubmed/26564861 http://dx.doi.org/10.1091/mbc.E15-04-0246 Text en © 2015 Morrow and Lechler. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.
spellingShingle Perspective
Morrow, Angel
Lechler, Terry
Studying cell biology in the skin
title Studying cell biology in the skin
title_full Studying cell biology in the skin
title_fullStr Studying cell biology in the skin
title_full_unstemmed Studying cell biology in the skin
title_short Studying cell biology in the skin
title_sort studying cell biology in the skin
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642852/
https://www.ncbi.nlm.nih.gov/pubmed/26564861
http://dx.doi.org/10.1091/mbc.E15-04-0246
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